Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (6): 77-82.doi: 10.6040/j.issn.1673-3770.0.2020.537

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Neuroendocrine carcinoma of the nasal cavity and paranasal sinus: eight cases and literature review

CHEN Xuejun, GAO Wen, YIN Gaofei, GUO Wei, HUANG Junwei, ZHANG Yang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University / Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Beijing 100730, China
  • Published:2021-12-10

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Abstract: ObjectiveTo investigate the clinical and pathological features, treatment, prognosis, and prognostic factors of neuroendocrine carcinoma of the nasal cavity and paranasal sinus. MethodsThe clinical data of 8 pathologically confirmed primary neuroendocrine carcinomas of the nasal cavity and paranasal sinus were reviewed. ResultsThe followup durations were 570 months, with a median of 23 months. Eight cases of nasal sinus neuroendocrine carcinoma were reviewed: 1 case of typical carcinoid tumor, 4 cases of atypical carcinoid tumor, 2 cases of small cell neuroendocrine carcinoma, and 1 case of complex neuroendocrine carcinoma (poorly differentiated neuroendocrine carcinoma with varus papilloma). The mean age of the patients was 46 years (3457 years). The stage of the malignant tumor in the nasal cavity and paranasal sinus was T2 in 2 patients and T4 in 6 patients. The cases were treated as follows: surgery, 7 cases; radiotherapy, 6 cases; and chemotherapy, 6 cases. Surgery plus postoperative chemoradiotherapy was the most common treatment. Conclusion The final diagnosis of neuroendocrine carcinoma depends on postoperative pathological and immunohistochemical indicators. The major adverse prognostic factors affecting the survival rate included the pathological subtypes and the associated treatment options. Surgical treatment is the first choice for typical and atypical carcinomas. For poorly differentiated subtypes of neuroendocrine carcinoma, comprehensive treatment is the most effective method for local tumor control and prolonged survival.

CLC Number: 

  • R739.62
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