Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 40-44.doi: 10.6040/j.issn.1673-3770.0.2021.368

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Expression and clinical significance of CIP2A in hypopharyngeal carcinoma

CHENG Yao1, ZHANG Zhen1, YANG Ji2, FENG Chengmin1, DENG Qicheng1, ZHANG Xi1, ZHAO Rui1, ZHU Xin1, WU Junzhi1, LIU Hai1, DENG Shishan3   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Neijiang Second People's Hospital, Neijiang 641000, Sichuan, China;
    3. Department of Human Anatomy, North Sichuan Medical College, Nanchong 637000, Sichuan, China
  • Published:2022-04-15

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Abstract: Objective To investigate the relationship between the expression of protein phosphatase 2A(CIP2A)and the clinicopathological features and prognosis of hypopharyngeal carcinoma. Methods Tissue samples from 58 patients with hypopharyngeal cancer, including 20 cases with paired paracarcinoma tissue samples, were collected in the Department of Pathology, Affiliated Hospital of North Sichuan Medical College from January 2016 to December 2020; 30 normal hypopharyngeal tissue samples were selected for comparison. Results Immunohistochemical SP showed that the expression level of CIP2A in hypopharyngeal carcinoma tissue was significantly higher than that in paracarcinoma and normal hypopharyngeal tissue(P<0.001). CIP2A expression was significantly related to alcohol consumption, pathological differentiation, clinical stage and lymph node metastasis(P<0.05), but had no significant relationship with gender, age, smoking status, or clinical type. Univariate log-rank analysis showed that age, clinical stage and CIP2A expression were correlated with prognosis(P<0.05). Cox proportional regression model analysis revealed that CIP2A expression was an independent risk factor for the prognosis of hypopharyngeal cancer. Conclusion The abnormal expression of CIP2A in hypopharyngeal cancer tissue suggests that this protein may be involved in the occurrence and development of tumors. Patients with hypopharyngeal cancer with high expression of CIP2A have a poor prognosis. Therefore, CIP2A may be a useful molecular marker for diagnosis, treatment and prognosis of hypopharyngeal cancer patients.

Key words: Hypopharyngeal cancer, CIP2A, Immunohistochemistry, Prognosis

CLC Number: 

  • R739.6
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