Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (4): 159-165.doi: 10.6040/j.issn.1673-3770.0.2023.077

• Review • Previous Articles    

Current status of experimental models and applications of meibomian gland dysfunction

BI Zhaojing1,2, LI Yuanbin2   

  1. 1. School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China2. Department of Ophthalmology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Published:2024-07-09

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Abstract: Meibomian gland dysfunction(MGD)is a common ocular surface disease in clinics that seriously affects the quality of patients' daily life. To date, related research on the pathogenesis and treatment of MGD has gradually become a research hotspot in dry eye. Therefore, the establishment of a stable and effective experimental model is a prerequisite for further exploration of MGD. The experimental models of MGD are divided into two categories: in vivo and in vitro models. The in vivo model is modeled mainly by drug induction, surgical induction, gene knockout, and transgenic methods. The in vitro model is used to simulate the pathophysiology of meibomian glands in vitro. This paper briefly reviews several MGD experimental models reported so far and their evaluation.

Key words: Meibomian gland dysfunction, Dry eye, iHMGEC, Meibomian gland explant, Animal models

CLC Number: 

  • R777.1
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