Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (3): 151-156.doi: 10.6040/j.issn.1673-3770.0.2023.413

• Review • Previous Articles    

Research progress on pigment epithelial derived factor and dry eye

YE Qiang1, LUOSONG Bazong2, NAN Suting1, WANG Hao1, MA Jinhai3, LYU Peng1, ZHANG Wenfang1   

  1. 1. Department of Ophthalmology, the Second Hospital of Lanzhou University, Lanzhou 730030, Gansu, China2. Health Center of Zhongcang Town, Nima County, Nagqu 853213, Xizang, China3. Lanzhou Bright Ophthalmology, Lanzhou 730030, Gansu, China
  • Published:2024-06-04

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Abstract: Dry eye is one of the ocular surface diseases seriously endangering the quality of human vision. In recent years, its incidence rate has increased year by year. However, the specific pathogenesis has not been clarified yet. The effects of ocular surface inflammation, oxidative stress, apoptosis of ocular surface cells, and reduction of nutritional protective factors in the occurrence of it have attracted much attention. Pigment epithelial derived factor(PEDF)is a natural neovascular inhibitor, which has biological functions such as inhibiting inflammatory response, resisting stress response, anti apoptosis, nourishing nerves and protecting cells. The latest studies suggest that PEDF plays important roles in the pathogenesis of it. In this review, the mechanism and potential therapeutic effects of PEDF in the occurrence and development of dry eye are briefly summarized, so as to further study the role of PEDF in dry eye and provide new ideas for the treatment of it in the future.

Key words: Dry eye, Pigment epithelium-derived factor, Inflammation, Review

CLC Number: 

  • R777.2
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