Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 71-77.doi: 10.6040/j.issn.1673-3770.0.2023.028

• Clinical Research • Previous Articles    

Correlations between vocal cord hyperplastic lesions, vocal cord leukoplakia, chronic laryngopharyngitis, and laryngopharyngeal reflux

WANG Lei1, WANG Gang1,2, SUN Zhezhe1, LIU Hongdan1, HAN Haolun1, LI Baowei1, ZHANG Xiaoli1, WU Wei1,2   

  1. 1. Department of Otolaryngology, the Ninth Medical Centerof Chinses PLA General Hospital, Beijing 100101, China2. State Environmental Protection Key Laboratony of Enrironmental Sense Organ Stress and Health, Beijing 100101, China
  • Published:2024-12-13

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Abstract: Objective The purpose of this study was to explore the correlations between vocal cord hyperplastic lesions, vocal cord leukoplakia, chronic laryngopharyngitis, and laryngopharyngeal reflux(LPR). Methods A retrospective analysis of 153 patients with benign vocal cord hyperplastic lesions(including 92 cases of vocal cord polyps, 24 cases of vocal cord cyst, and 37 cases of Reinke’s edema), 53 patients with vocal cord leukoplakia, and 106 patients with chronic laryngopharyngitis was performed. Reflux symptom index(RSI), reflux finding score(RFS), and oropharyngeal pH monitoring results were analyzed. The positive rate of LPR and the reflux-related indexes of each group were compared. Multi-factor logistic regression analysis was performed and included age, sex, smoking, and drinking habits. Results The prevalence of LPR in the vocal cord lesion group(benign vocal cord hyperplastic lesions and leukoplakia)was significantly higher than in the laryngopharyngitis group, according to the RSI, RFS, Ryan score, W score, and other parameters of oropharyngeal pH monitoring(P<0.05). The leukoplakia group had the lowest positive rate of RSI, but the reflux-related parameters of pH monitoring were significantly higher than those in other groups(P<0.05). The positive rate and W score in the vocal cord cyst group were second to those in the leukoplakia group. Multivariate analysis showed that LPR was an independent risk factor for leukoplakia, except for old age, male, and smoking. LPR was also a risk factor for vocal cord cysts when W score was considered as the standard. Conclusions LPR is associated with a variety of laryngeal diseases. Vocal cord hyperplastic lesions and leukoplakia are related to LPR more closely than laryngopharyngitis disease, especially leukoplakia. Further studies to validate the relationship between vocal cord cysts and LPR are necessary.

Key words: Laryngopharyngeal reflux, Vocal cord hyperplastic lesions, Vocal cord leukoplakia, Dx-pH monitoring

CLC Number: 

  • R766.5
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