Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 30-34.doi: 10.6040/j.issn.1673-3770.0.2022.150

• 论著 • Previous Articles     Next Articles

Nasal ameloblastoma: a case report and literature analysis

LI Xiaoying1, LI Yan2, WU Yungang3, ZHANG Hui3, MA Linxiang3, ZHAO Yufeng3, SUN Juxing3, ZHANG Jin1   

  1. 1. School of Clinical Medicine, Jining Medical University, Jining 272000, Shandong, China;
    2. Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong, China;
    3. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of Jining Medical College, Jining 272000, Shandong, China
  • Published:2023-05-24

PDF (PC)

558

Abstract: Objective To investigate the clinical characteristics and treatment of nasal ameloblastoma for its early detection and diagnosis. Methods The clinical data of one patient with nasal ameloblastoma were retrospectively analyzed and the related literatures were reviewed. Results Ameloblastoma occurred frequently in the oral cavity and jaw but rarely in the nasal cavity and sinus. Patients can present with nasal congestion and bleeding, tenderness in the sinus area, decreased vision, etc., and in severe cases, facial deformity can be caused. Imaging can determine the extent of the lesion and the relationship between adjacent tissues. The main treatment is complete removal of the lesion by surgery, combined with targeted therapy for comprehensive treatment. The postoperative recurrence rate is high, and ameloblastic carcinoma transformation is common. Conclusion Ameloblastoma of the nasal cavity is a rare and benign tumor but its biological behavior is invasive. The clinical manifestations and imaging examinations of patients are not specific and need to be confirmed by pathological biopsy.

Key words: Ameloblastoma, Tumor, Nasal cavity, Sinuses, Functional endoscopic sinus surgery

CLC Number: 

  • R765.4
[1] Lasisi TJ, Adisa AO, Olusanya AA. Appraisal of jaw swellings in a Nigerian tertiary healthcare facility[J]. J Clin Exp Dent, 2013, 5(1): 42-47. doi: 10.4317/jced.51011
[2] Oginni FO, Stoelinga PJ, Ajike SA, et al. A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma[J]. Int J Oral Maxillofac Surg, 2015, 44(9): 1099-1105. doi: 10.1016/j.ijom.2015.03.018
[3] Zeballos R, Bologna-Molina R, Pereira-Prado V, et al. Expression of parathyroid hormone related protein(PTHRP)in ameloblastomas[J]. J Clin Exp Dent, 2018, 10(2): 172-176. doi:10.4317/jced.54222
[4] Wilmot H, Hockley J, Rigsby P, et al. Establishment of the World Health Organization 2 nd international standard for factor XI, plasma, human[J]. Front Med(Lausanne), 2017, 4: 28. doi:10.3389/fmed.2017.00028
[5] 陶谦, 杨耀成. 2017年WHO成釉细胞瘤新分类的逻辑性与临床指导意义[J]. 口腔疾病防治, 2020, 28(7): 416-420. doi:10.12016/j.issn.2096-1456.2020.07.002 TAO Qian, YANG Yaocheng. Logic and clinical significance of the new WHO classification of ameloblastoma in 2017[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 416-420. doi:10.12016/j.issn.2096-1456.2020.07.002
[6] 贺娟, 申铁兵. 成釉细胞瘤的病理分型与治疗方式[J]. 中华老年口腔医学杂志, 2016, 14(2): 125-128. doi:10.3969/j.issn.1672-2973.2016.02.015 HE Juan, SHEN Tiebing. Ameloblastoma pathological classification and treatment[J]. Chinese Journal of Geriatric Dentistry, 2016, 14(2): 125-128. doi:10.3969/j.issn.1672-2973.2016.02.015
[7] McClary AC, West RB, McClary AC, et al. Ameloblastoma: a clinical review and trends in management[J]. Eur Arch Otorhinolaryngol, 2016, 273(7): 1649-1661. doi:10.1007/s00405-015-3631-8
[8] Dissanayake RK, Jayasooriya PR, Siriwardena DJ, et al. Review of metastasizing(malignant)ameloblastoma(METAM): pattern of metastasis and treatment[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endo, 2011, 111(6): 734-741. doi:10.1016/j.tripleo.2010.12.018
[9] Harada H, Kimura S, Kimura Y, et al. Sinonasal ameloblastoma: a case report focusing on histogenesis and related morphological characteristics[J]. Oral Maxillofac Surg Cases, 2020, 6(4): 100201. doi:10.1016/j.omsc.2020.100201
[10] Goh YC, Siriwardena BSMS, Tilakaratne WM. Association of clinicopathological factors and treatment modalities in the recurrence of ameloblastoma: analysis of 624 cases[J]. J Oral Pathol Med, 2021, 50(9): 927-936. doi:10.1111/jop.13228
[11] 韩兴冰. 成釉细胞瘤的X线与CT诊断分析[J]. 实用心脑肺血管病杂志, 2010, 18(12): 1856-1858. doi:10.3969/j.issn.1008-5971.2010.12.071 HAN Xingbing. X-ray and CT diagnosis of ameloblastomas[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2010, 18(12): 1856-1858. doi:10.3969/j.issn.1008-5971.2010.12.071
[12] 钟振华, 程泽星, 王磊. 鼻腔鼻窦造釉细胞瘤临床分析[J]. 中国耳鼻咽喉头颈外科, 2018, 25(2): 101-103. doi:10.16066/j.1672-7002.2018.02.012 ZHONG Zhenhua, CHENG Zexing, WANG Lei. Clinical analysis of ameloblastoma in nasal cavity and paranasal sinuses[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2018, 25(2): 101-103. doi:10.16066/j.1672-7002.2018.02.012
[13] Pandiar D, Anand R, Kamboj M, et al. Metastasizing ameloblastoma: a 10 year clinicopathological review with an insight into pathogenesis[J]. Head Neck Pathol, 2021, 15(3): 967-974. doi:10.1007/s12105-020-01258-5
[14] Goh YC, Siriwardena BSMS, Tilakaratne WM. Association of clinicopathological factors and treatment modalities in the recurrence of ameloblastoma: analysis of 624 cases[J]. J Oral Pathol Med, 2021, 50(9): 927-936. doi:10.1111/jop.13228
[15] 吴文源, 林泼水, 洪育明, 等.开窗联合刮除术治疗下颌骨巨型囊性成釉细胞瘤12例[J]. 山东大学耳鼻喉眼学报, 2010, 24(6):64-66 WU Wenyuan, LIN Poshui, HONG Yuming, et al. The combination of fenestration with curettage in the treatment of mandibular giant cystic ameloblastoma(12 cases)[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2010, 24(6): 64-66
[16] Pandiar D, Anand R, Kamboj M, et al. Metastasizing ameloblastoma: a 10 year clinicopathological review with an insight into pathogenesis[J]. Head Neck Pathol, 2021, 15(3): 967-974. doi:10.1007/s12105-020-01258-5
[17] You Z, Liu SP, Du J, et al. Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: a review[J]. J Oral Pathol Med, 2019, 48(3): 201-205. doi:10.1111/jop.12807
[18] Barrena BG, Phillips BJ, Moran KJ, et al. Sinonasal ameloblastoma[J]. Head Neck Pathol, 2019, 13(2): 247-250. doi:10.1007/s12105-018-0933-3
[1] TANG Jiajun, HOU Jie, DOU Xin, YU Chenjie. Advances in CT research on the impact of nasal framework deformation on nasal cavity structure and sinus pneumatization [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 102-110.
[2] PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling. Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 95-98.
[3] LI Demin, DONG Nian, MA Xu, ZHANG Jin, DING Detao, WU Yungang. Granular cell tumor of the hypopharynx:two cases report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 126-132.
[4] HU Yi, KONG Xuhui. Research progress on the mechanism of complement in the development of laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 148-155.
[5] GUO Rongchang, LIU Qinghang, WANG Hongzeng, SUN Shujun. Through the orbit with sinus huge foreign bodies embedded in the base of the skull: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 135-141.
[6] WANG Hua, ZHANG Fengzhen, LONG Ting, ZHAO Jing, LI Hongbin, WANG Shengcai, WANG Guixiang. Analysis of the reasons and prognostic outcomes for tracheostomy in pediatric patients following posterior fossa tumor resection [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 168-173.
[7] SHI Jinlian, LI Jianxing, HUANG Yousheng, LIN Mingxuan, LIU Lingyun, LU Yongtian. Research status and progress in diagnosis and treatment of laryngeal inflammatory myofibroblastic tumor [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 186-192.
[8] ZENG Qiying, ZHU Huaming, GUAN Jian, WU Hongmin, YE Haibo, YI Hongliang. Bipolar coagulation forceps applied in the treatment of 6 cases of shamblin type III carotid body tumors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 70-76.
[9] YU Haonan, ZHONG Yingying, WANG Xinmeng, ZHANG Min, JIANG Qingmin, LI Nan, LI Yan. Therapeutic effects of human umbilical cord mesenchymal stem cells induced by TNF-α on limbal stem cell deficiency in mice [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 141-147.
[10] HOU Jing, FANG Gaoli, ZHOU Bing. Formation mechanism and cyst fluid composition analysis of nasal mucosal cysts after functional endoscopy sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 1-5.
[11] PENG Yuting, LI Jianhao, WANG Yan. Orbital apex syndrome secondary to nasal-orbital-skull base malignant tumor: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 105-111.
[12] WANG Yang, HU Yue, LI Xiaoming, QI Wenwen, ZHANG Jie, ZHANG Hao, WANG Qianqian, XU Fenglei, JIA Tao, XIA Ming. Three-dimensionally printed titanium prosthesis for repair of large tracheal defect: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 121-125.
[13] ZHANG Jingyi, DONG Xiangyi, MU Yakui, SONG Xicheng. Research progress on pyroptosis in otorhinolaryngology diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 140-148.
[14] YANG Kaiyan, TANG Fengzhu, QIN Qicai, LI Xuxiang, FENG Dayi, NONG Fengjing, YANG Qiuyun. Expression of abnormal spindle-like microcephaly associated protein in nasopharyngeal carcinoma and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 18-25.
[15] LI Hao, YANG Liyuan, ZHANG Shoukai. Short-term clinical observation of drugsustained-release stent implantation in patients with refractory sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 38-42.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd