JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of the Ras-GTPase-activiting protein SH 3 domain binding protein
in laryngeal squamous cell carcinoma and it clinical significance

XU Zhi-jian 1,2，PENG Jie-ren1, HUANG Xiao-ming1, GUAN Zhong1, ZHU Xiao-fen2, LIAO Yan-ping2   

  1. 1. Department of Otolaryngology, Affiliated Second Hospital of Sun Yet-sen University, Guangzhou 510120, China;2. Huizhou Central People′s Hospital, Huizhou 516001, Guangdong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-10-16 Published:2008-10-16
  • Contact: PENG Jie-ren

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Abstract: To investigate the expression of the Ras-GTPase-activiting protein SH 3 domain binding protein(G3BP) in laryngeal squamous cell carcinoma(LSCC) and to explore its correlation with biological behavior. MethodsThe expressions of G3BP in 91 cases of LSCC were determined by immunohistochemistry. The relationships between protein expression and tumor size, differentiation degree, TNM stage, lymph node metastasis and prognosis of LSCC were explored. ResultsThe positive expression rate of G3BP in LSCC was 84.7％. The G3BP expression level was correlated with the degree of differentiation of tumors（P=0.008）, clinical stage（P=0.005）, lymphatic metastasis（P=0.000）,　and tumor recurrence or distant metastasis（P=0.000）, and also the expression of G3BP was significantly related to survival in a negative time-dependent manner in LSCC patients（P=0.000）. ConclusionsThe expression of G3BP is related to the degree of differentiation of tumors， clinical stage, tumor recurrence or distant metastasis, lymphatic metastasis and survival in LSCC patients. Over-expression of G3BP may be used as a prognostic marker for overall survival of LSCC patients.

Key words: Ras-GTPase-activiting protein SH 3 domain binding protein, Immunohistochemistry, Laryngeal squamous cell carcinoma

CLC Number: 

  • R739.65
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