Abstract: Objective To investigate the effects of budesonide combined with saline nasal irrigation on chronic rhinosinusitis(CRS)and nasal secretion of interleukin(IL)-6, IL-8, and tumor necrosis factor-alpha(TNF-α). Methods One hundred and twenty-eight subjects were selected for the study from the patients with CRS treated in our hospital from February 2016 to May 2017. They were divided using a random number table generator into a control group that received saline nasal lavage alone(n=64)and an observation group that received saline nasal lavage to which budesonide suspension was added(n=64). The clinical efficacy and changes in IL-6, IL-8 and TNF-α levels in nasal secretions, the Lund-Kennedy score for the nasal cavity, and the computed tomography score for the paranasal sinuses were compared between the two groups before and after 4 weeks of treatment. Results The efficacy rate was significantly higher in the observation group than in the control group(93.75% ［60/64］ vs. 71.88% ［46/64］; P<0.01). The nasal Lund-Kennedy and paranasal sinus computed tomography scores were significantly lower in both study groups after treatment than before treatment(P<0.01); however, the decreases in these scores were significantly greater in the observation group(P<0.01). The IL-6, IL-8, and TNF-α levels in nasal secretions were also significantly lower in both study groups after treatment than before treatment(P<0.01); however, the decreases in levels of these inflammatory markers were significantly greater in the observation group(P<0.01). No obvious adverse reactions occurred in either study group during treatment. Conclusion Budesonide combined with saline nasal irrigation can significantly relieve nasal inflammation, help to relieve symptoms such as nasal congestion and swelling, and have a curative effect in patients with CRS.

Key words: Budesonide, Inflammatory factor, Rhinosinusitis, chronic, Nasal irrigation