Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (2): 110-114.doi: 10.6040/j.issn.1673-3770.0.2019.530

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Prognostic role of preoperative fibrinogen levels in patients with laryngeal squamous cell carcinoma

CHEN Huijun, SONG Shenghua, DONG Weida, ZHOU Han   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2020-04-07

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Abstract: Objective This study aimed to evaluate the impact of preoperative fibrinogen(FIB)on the prognosis of patients with laryngeal squamous cell carcinoma. Methods The clinical data of 458 patients with laryngeal squamous cell carcinoma who underwent primary surgery in the First Affiliated Hospital of Nanjing Medical University were analyzed retrospectively. On observation of preoperative FIB levels, a receiver operating characteristic curve(ROC)was drawn to determine the FIB threshold, and then the patients were divided into lower and higher groups. Chi-square test, Kaplan-Meier analysis and Cox risk model were used to analyze the relationship between FIB, other clinicopathological parameters and overall survival. Results The area under the ROC curve(AUC)of FIB for overall survival(OS)of patients with laryngeal squamous cell carcinoma was 0.67. Univariate analysis showed that FIB, tumor classification, TNM stages, pathological differentiation, invasion of thyroid cartilage plate, lymph nodes metastasis and age were associated with OS of patients with laryngeal squamous cell carcinoma. Cox regression model identified high FIB level, TNM stages III and IV, and age as independent risk factors for the OS of patients with laryngeal squamous cell carcinoma (P<0.001; P=0.014; P=0.003). Conclusion Patients with laryngeal squamous cell carcinoma and high preoperative FIB levels are more likely to have lower OS. It could be a clinical biomarker for the prognosis of laryngeal squamous cell carcinoma.

Key words: Laryngeal squamous cell carcinoma, Fibrinogen, Overall survival, Prognosis

CLC Number: 

  • R767
[1] 黄选兆, 汪吉宝, 孔维佳. 实用耳鼻咽喉头颈外科学[M]. 北京: 人民卫生出版社,2008:488.
[2] Koodziejczyk J, Ponczek MB. The role of fibrinogen, fibrin and fibrin(ogen)degradation products(FDPs)in tumor progression[J]. Contemp Oncol(Pozn), 2013, 17(2): 113-119. doi:10.5114/wo.2013.34611.
[3] Diao DM, Cheng Y, Song YC, et al. D-dimer is an essential accompaniment of circulating tumor cells in gastric cancer[J]. BMC Cancer, 2017, 17(1): 56. doi:10.1186/s12885-016-3043-1.
[4] Yu XF, Hu FL, Yao Q, et al. Serum fibrinogen levels are positively correlated with advanced tumor stage and poor survival in patients with gastric cancer undergoing gastrectomy: a large cohort retrospective study[J]. BMC Cancer, 2016, 16: 480. doi:10.1186/s12885-016-2510-z.
[5] Otten HM, Prins MH. Venous thromboembolism and occult malignancy[J]. Thromb Res, 2001, 102(6): V187-V194. doi:10.1016/s0049-3848(01)00235-3.
[6] Zhu Y, Zhang LH, Zha HR, et al. Stroma-derived fibrinogen-like protein 2 activates cancer-associated fibroblasts to promote tumor growth in lung cancer[J]. Int J Biol Sci, 2017, 13(6): 804-814. doi:10.7150/ijbs.19398.
[7] Liu YL, Lu Q, Liang JW, et al. High plasma fibrinogen is correlated with poor response to trastuzumab treatment in HER2 positive breast cancer[J]. Medicine(Baltimore), 2015, 94(5): e481. doi:10.1097/MD.0000000000000481.
[8] 张礼, 燕锦. 血浆纤维蛋白原在结直肠癌中的研究进展[J]. 肿瘤预防与治疗, 2016, 29(4): 231-234. doi:10.3969/j.issn.1674-0904.2016.04.009.
[9] 陈慧君, 宋圣花, 周涵, 等. 血小板与淋巴细胞比值对喉癌复发的预测价值[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 106-110. doi:10.6040/j.issn.1673-3770.1.2019.018. CHEN Huijun, SONG Shenghua, ZHOU Han, et al. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for laryngeal squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 106-110. doi:10.6040/j.issn.1673-3770.1.2019.018.
[10] Kucharczyk J, Sullivan C, Lu J, et al. Prognostic and Predictive Value of Pretreatment Derived Neutrophil-to-Lymphocyte Ratio in Non-Small-Cell Lung Cancer Patients Treated with an Immune Checkpoint Inhibitor[J]. J Cancer Ther, 2018, 9(1): 23-34. doi:10.4236/jct.2018.91004.
[11] Lin Y, Liu Z, Qiu Y, et al. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: A systematic review and meta-analysis[J]. European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2018,44(10):1494-1503. doi: 10.1016/j.ejso.2018.07.052.
[12] Grafetstatter M, Husing A, Gonzalez Maldonado S, et al. Plasma Fibrinogen and sP-Selectin are Associated with the Risk of Lung Cancer in a Prospective Study[J]. Cancer epidemiology, biomarkers & prevention. 2019,28(7):1221-1227. doi:10.1158/1055-9965.EPI-18-1285.
[13] Sahni A, Simpson-Haidaris PJ, Sahni SK, et al. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2(FGF-2)[J].J Thromb Haemost, 2008, 6(1): 176-183. doi:10.1111/j.1538-7836.2007.02808.x.
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