Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (4): 23-27.doi: 10.6040/j.issn.1673-3770.1.2020.059

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Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract:

Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.   

  1. Key words:Ocular ischemic syndrome;
    Fluorescein angiography;
    Optical coherence tomography angiography;
    Cell therapy眼缺血综合征(ocular ischemic syndrome, OIS)是由同侧颈总动脉或颈内动脉狭窄或阻塞导致眼动脉(视网膜中央动脉及睫状前/后动脉)低灌注, 而产生一系列脑部和眼部症状的慢性进行性眼病。1963年Hedges［1］首次报道颈内动脉闭塞患者不仅存在对侧肢体运动及感觉障碍, 并且合并一系列眼部症状, 如一过性黑矇、视物模糊等。除此之外, Hedges观察到此类患者视网膜存在静脉扩张和周边点片状出血, 由此提出颈动脉供血不足引起视网膜缺血缺氧的理论基础。OIS起病隐匿, 眼部表现复杂多样, 且容易被其他眼血管疾病掩盖, 如糖尿病性视网膜病变和视网膜静脉阻塞等, 因此临床上容易漏诊或误诊, 导致患者不可逆的视力丧失, 5年死亡率高达40%, 患者大多死于心肌梗死和脑梗死等心脑血管事件［2-3］。因此, OIS需要眼科、神经科和心脏病科等多学科综合诊疗, 通过大规模临床研究, 建立OIS医学数据库, 进一步规范多学科诊疗流程, 对于降低患者的患盲率和死亡率是至关重要的。
  • Received:2020-06-21 Online:2020-07-20 Published:2020-08-28

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Abstract: Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.

Key words: Ocular ischemic syndrome, Fluorescein angiography, Optical coherence tomography angiography, Cell therapy

CLC Number: 

  • R771.3
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[13] Ocular ischemic syndrome(OIS)is a severe ophthalmic disease caused by ocular hypoperfusion, which occurs due to stenosis or occlusion of the common or internal carotid arteries. The clinical presentations and signs of OIS are complex, incidental, and different. OIS is easily misdiagnosed or remains undiagnosed because of its asymptomatic onset and complicated ocular manifestations. Therefore, it is crucial to trace the etiology of OIS. Presently, different imaging modalities can evaluate the carotid artery blood supply, collateral circulation, and brain perfusion. Thus, appropriate modalities must be selected for OIS diagnosis based on their advantages and disadvantages. Furthermore, the auxiliary examination results should be accurately and promptly considered and interpreted when establishing a diagnosis of OIS. Thus, the management of OIS requires cooperation with ophthalmologists, cardiologists, and neurologists.. Correct interpretation of the predictors of ocular ischemic syndrome to improve diagnostic performance HUANG Yingxiang, WANG Yanling Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Abstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 1-4.
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[15] ObjectiveObjectiveTo analyze the literature on ocular ischemic syndrome published between January , and December , . MethodPapers on OIS that were published between January , and December , , were screened and retrieved from the CNKI and WOS databases, and those that were relevant were searched and analyzed. ResultsIn this analysis, Chinese papers on OIS were cited for times with an h-index of , while foreign papers were cited for times with an h-index of . Of the organizations that published the highest number of papers and had the highest h-indexes, the Capital Medical University and the Polish Medical University of Pomerania were the leading institutions. The Chinese Journal of Ophthalmology was the leading domestic journal, and the Journal of Ophthalmology and Plos One were the leading foreign journals. China published the highest number of papers abroad, China and South Korea had the highest h-indexes. China′s National Natural Science Foundation provided the most support to the field of OIS, accounting for .% of the total domestic literature. The most frequently cited article in the WOS database was by Hayreh, SS, which was on the prevalence and pathogenesis of ocular vascular occlusive disease and melanosis, it was also part of the top ten studies that focused on the utility of OCT in providing insights into OIS and the mechanisms of ischemia and hypoxia. ConclusionThe utility of OCT in providing insights into OIS and the mechanisms of hypoxia and ischemia represents a modern focus of researchers.. Analysis of the literature on ocular ischemic syndrome at home and abroadMENG Bo, HUANG Yingxiang, WANG Kang, ZHAO Lu, WANG Yanling Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 35-40.
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