Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 99-103.doi: 10.6040/j.issn.1673-3770.0.2020.250

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Preoperative timing and the effect of intravitreal aflibercept injection for proliferative diabetic retinopathy patients

LIU Zhigao1,2, WANG Shuya1, HAN Xuguang2, WANG Yu2, LI Zhiwei2, MA Aihua3, ZHAO Bojun1,3   

  1. 1. Department of Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan 250300, Shandong, China;
    2. Department of Ophthalmology, Jinan Aier Eye Hospital, Jinan 250100, Shandong, China;
    3. Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan 250000, Shandong, China
  • Published:2021-02-01

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Abstract: Objective To investigate the changes in vitreous inflammatory and angiogenic cytokine levels after administering intravitreal aflibercept(IVA)in the eyes with proliferative diabetic retinopathy(PDR). Methods A prospective comparative study was performed of the clinical data of the PDR patients who had undergone 23-gauge vitrectomy. Patients were divided into three groups: group A(16 eyes of 16 patients), without IVA administered preoperatively; group B(18 eyes of 18 patients), with IVA 2.0 mg administered 3 days preoperatively; and group C(18 eyes of 18 patients), with IVA 2.0 mg administered 6 days preoperatively. A total of 15 patients with idiopathic epiretinal membrane or idiopathic macular hole were selected as controls(group D). The vitreous humor was collected at the beginning of vitrectomy. The vitreal factors, including the vascular endothelial growth factor(VEGF)and basic fibrosis growth factor, were measured using the cytometric bead array. Results Higher levels of VEGF(P<0.05)in groups A, B, and C were observed compared to group D. However, VEGF levels were significantly higher in group A than in groups B and C(P<0.05). Conclusions IVA is effective in reducing the level of VEGF. IVA administered 3 to 6 days preoperatively is optimal and can help reduce complications.

Key words: Neovascularization, Proliferative diabetic retinopathy, Angiogenic and inflammatory cytokines, Vitrectomy, Aflibercept

CLC Number: 

  • R774
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