Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 15-19.doi: 10.6040/j.issn.1673-3770.0.2022.034

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Advancements in the diagnosis and treatment of chronic sinusitis based on phenotypes and endotypes

XIONG Panhui, SHEN YangOverview,YANG Yucheng   

  1. Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Published:2022-06-15

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Abstract: Chronic rhinosinusitis(CRS)is a heterogeneous disease with complex phenotypes and endotypes. Depending on the presence or absence of nasal polyps, CRS phenotypes can be classified as with or without polyps. Other phenotypic classifications of CRS include allergies, asthma, and aspirin intolerance. In recent years, breakthroughs have been made in research on the pathogenesis of CRS endotypes, such as type 2 inflammation and non-type 2 inflammation, and effective biological agents have been introduced for the treatment of CRS. This article describes the latest phenotype and endotype classification of chronic rhinosinusitis and the latest treatment progress based on phenotypes and endotypes. The identification of specific endotype and phenotype combinations will allow more accurate diagnoses of chronic rhinosinusitis and personalized treatments in the future.

Key words: Chronic sinusitis, Phenotype, Endotype, Diagnosis, Treatment

CLC Number: 

  • R765
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