慢性鼻窦炎伴鼻息肉的内型研究及其指导下的精准控制与治疗

doi:10.6040/j.issn.1673-3770.1.2022.005

Abstract

Abstract: Chronic rhinosinusitis with nasal polyps(CRSwNP)refers to chronic inflammation of the nasal cavity and paranasal sinuses with polyp formation over a course of more than 12 weeks. CRSwNP covers a group of complex diseases with similar phenotypes, but significantly different underlying mechanisms. Based on the inflammatory factors involved and the pathological mechanisms, CRSwNP can be divided into type 1, 2, and 3 inflammation, among which type 2 inflammation corresponds to CRSwNP dominated by eosinophil infiltration. There are many differences in the clinical manifestations, demographic characteristics, treatment responses, and prognosis of the different endotypes. Therefore, to optimize diagnosis, it is necessary to establish indirect predictive models that are based on the clinical characteristics and an in-depth of the different pathological mechanisms. Furthermore, the accurate control and treatment of symptoms can also be achieved to improve prognosis, under the guidance of endotypes. This article reviews the current progresses in the field of CRSwNP endotypes and their precise control and treatment under clinical guidance.

Key words: Chronic rhinosinusitis, Nasal polyps, Endotype, Type 2 inflammation, Biologics

CLC Number:

R765.41

AO Tian,CHENG Lei. An endotype study of chronic rhinosinusitis with nasal polyps and precise control and treatment under the guidance[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 7-14.

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