Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 84-91.doi: 10.6040/j.issn.1673-3770.0.2021.562

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The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps

LI Jiani1, ZHU Dongdong1,2Overview,MENG Cuida1,2   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China;
    2. Jilin provincial Key Laboratory of Precise Diagnosis and Treatment of Upper Airway Allergic, Changchun 130033, Jilin, China
  • Published:2022-06-15

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Abstract: The pathogenesis of chronic rhinosinusitis(CRS)with nasal polyps has not been fully elucidated. Epigenetics mainly refers to changes in gene expression levels based on non-gene sequence changes, such as DNA methylation, histone modification, and microRNA regulation. In this review, the role of epigenetic modification of CRS-related genes and changes in the expression levels of corresponding cytokines and other related proteins in the pathogenesis of CRS are discussed. The aim of this review is to provide new directions for research on the pathogenesis of CRS and the development of therapeutic methods.

Key words: Chronic Rhinosinusitis, Nasal Polyps, Epigenetics, Methylation, Pathogenesis

CLC Number: 

  • R765.4
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