JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Effect of Paclitaxel on the hearing threshold in guinea pigs

JIANG Yi, LI Rui-yu, CHEN Yong   

  1. Department of Otolaryngology, Fujian Provincial Hospital, Clinical Medical Institute of Fujian Medical University,Fuzhou 350001, Fujian, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: JIANG Yi

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Abstract: Objective: To investigate the effects of Paclitaxel on the hearing threshold in guinea pigs. Methods: Thirty female guinea pigs were randomly divided into one control group and five experimental groups. The control group received no medications while the five experimental groups were intraperitoneallly subjected with different doses of Paclitaxel. Prior to medication and after the ending of medication, all animals underwent auditory brainstem response (ABR) testing bilaterally. Results: Hearing levels were significantly decreased in the experimental groups. No correlation was found between the dose given and the degree of hearing loss. Conclusion: Paclitaxel causes mild to moderate sensorineural hearing loss.

Key words: Paclitaxel, Hearing loss, Auditory brainstem responses

CLC Number: 

  • R764.43
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