Abstract: Objective To explore the clinical efficacy of the epithelial laser in situ keratomoleusis(EPI-LASIK) in the treatment of myopia. Methods During the EPI-LASIK for 268 cases (518 eyes), the corneal sub-epithelial valve was made by means of the nasal side for stem and LASIK was performed with Moria, then the corneal sub-epithelial valve was reset and contact lens were used for 3 to 5 days. All the patients were followed up for 3 to 6 months, and the postoperative symptoms, the healing conditions of cornea, naked vision, diopter EPI and Haze were observed. Results During the operations, the corneal sub-epithelial valve was made well, and 5 days after operations, the epithelium of 486 eyes healed well and contact lens were not used. 30 eyes had corneal edema in fragmentis and they had no adverse effects when the lens were picked off on time. 2 eyes had corneal edema of large areas and healed well when the lens were picked off 2 days later. The best corrected visual acuity did not decrease 3 months after operations, and it was raised 1 or 2 lines in 58 eyes.The cornea Haze of 54 eyes was 0.5, of 16 eyes was 1 and the rest were transparent 3 months after operations. 384 eyes were followed up for 6 months, 22 had Haze 0.5 and 8 had Haze 1. Conclusion EPI-LASIK has the benefits of safety, stability, and good predictability.

Key words: Keratomileusis, Laser, Myopia