山东大学耳鼻喉眼学报 ›› 2013, Vol. 27 ›› Issue (6): 12-15.doi: 10.6040/j.issn.1673-3770.0.2013.300

• 专题笔谈 • 上一篇    下一篇

甲状腺乳头状癌颈部淋巴结转移规律的临床分析

周鹏,贺青卿,庄大勇,范子义,郑鲁明,朱见,于芳,岳涛,董学峰   

  1. 济南军区总医院甲状腺乳腺外科, 济南 250031
  • 收稿日期:2013-10-22 发布日期:2013-12-16
  • 通讯作者: 贺青卿,硕士生导师。 Email:heqingqing@yeah.net
  • 作者简介:周鹏。 Email:weardzp@126.com
  • 基金资助:

    济南军区总医院院长基金资助(2011M03);中国博士后科学基金第三批特别资助项目(201003759)

Regularity of lymph node metastasis in papillary thyroid carcinoma

ZHOU Peng, HE Qing-qing, ZHUANG Da-yong, FAN Zi-yi, ZHENG Lu-ming, ZHU Jian, YU Fang, YUE Tao, DONG Xue-feng   

  1. Department of Thyroid and Breast Surgery, Jinan Military General Hospital, Jinan 250031, China
  • Received:2013-10-22 Published:2013-12-16

摘要:

目的    探讨甲状腺乳头状癌颈淋巴结转移规律,为选择最佳手术方式提供参考。方法    回顾分析2001年1月至2013年8月济南军区总医院甲状腺乳腺外科616例诊断为甲状腺乳头状癌患者的临床和病理资料。结果    616例有完整统计资料的甲状腺乳头状癌患者中,病理诊断颈部淋巴结总转移率为58.77%(362/616),中央区(Ⅵ区)淋巴结转移率为48.70%(300/616),颈侧区(Ⅱ、Ⅲ、Ⅳ、Ⅴ区)淋巴结转移率为38.80%(239/616),原发肿瘤的部位、最大直径、是否累及包膜、是否为多发病灶及患者年龄对颈部淋巴结转移率有显著影响,差异有统计学意义(P<0.05),且双因素方差分析显示,肿瘤直径越大,转移到颈侧区的可能性越大。结论    甲状腺乳头状癌最常见的转移部位是Ⅵ区,术中应常规清除,其次依次为Ⅲ、Ⅳ、Ⅱ、Ⅴ区,对于患者原发肿瘤具有累及包膜、直径>1cm、多发病灶及位于双侧等特点应清扫颈侧区,术中快速病理检查颈侧区淋巴结病理状态,确定颈侧区淋巴结清扫范围。

关键词: 颈淋巴结转移规律, 甲状腺乳头状癌, 颈部淋巴结清扫术

Abstract:

Objective    To explore the regularity of cervical lymph node metastasis of papillary thyroid carcinoma and to select an appropriate surgical method for papillary thyroid carcinoma. Methods    The clinical data of 616 cases of papillary thyroid carcinoma treated in this hospital between January 2001 and August 2013 were retrospectively analyzed. Results    The total lymph node metastasis rate was 58.77% (362/616). The lymph node metastasis rate was 48.70% (300/616) in level Ⅵ and was 38.80% (239/616) in level Ⅱ,  Ⅲ,  Ⅳ and Ⅴ.  There was significant relationship between the site of the original tumor, maximum diameter, amicula invasion, multifocality, age of patients and cervical lymph node metastasis (P<0.05). Conclusion    Lymph nodes of level Ⅵ should routinely be dissected in the first surgery in patients with thyroid papillary carcinoma. When the tumor is invaded to amicula, or whose diameter is >1.0cm or is multifocality, the cervical lymph node should be dissected and frozen biopsy should be made in the operations to determine the extend of lymphadenectomy.

Key words: Papillary thyroid carcinoma, Neck dissection, Cervical lymph node metastasis

中图分类号: 

  • R736.1
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[2] 王欣如1,2,刘志艳3,李丽珍1,黄涛2,夏斌4,李芳邻1,2. TGF-β1G-800A、C-509T单核苷酸基因多态性与甲状腺乳头状癌易感性的关系[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 28-32.
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