ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (1): 49-51.doi: 10.6040/j.issn.1673-3770.0.2014.342
张菊, 吴欣怡
ZHANG Ju, WU Xin-yi
摘要： 目的 观察0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症的疗效。方法 将60例(120眼)随机分为实验组与对照组,每组30例(60眼)。实验组每日给予0.1%环孢素滴眼液联合玻璃酸钠滴眼液,每日3次,1滴/次。对照组每日给予玻璃酸钠滴眼液,每日3次,1滴/次。两组均连续用药1个月。均以1个月为一疗程,治疗前后均行基础泪液分泌试验(SIt)、泪膜破裂时间(BUT)、角膜荧光素染色(FLs)检查,并对结果进行统计学分析。结果 治疗前两组SIt、BUT、FLs差异均无统计学意义(P>0.05)。治疗后两组SIt、BUT、FLs均较治疗前改善,差异有统计学意义(P<0.05)。治疗后实验组SIt、BUT、FLs优于对照组(P<0.05)。结论 0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症能有效缓解眼部不适症状,优于单用玻璃酸钠滴眼液。
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| [1] Jian G E . Ophthalmology[M]. Beijing: People's Health Press, 2010: 136-142. [2] Pfluqfelder S C. Anti-inflammatory therapy for dry eye[J]. Ocul Surf, 2003, 1(1):31-36. [3] Perry H D, Donnenfeld E D. Medications for dry eye syndrome: a drug-therapy review[J]. Manag Care, 2003, 12(12):26-32. [4] 庞雅菊,贾桂芹,冯金玲,等.0.05%环孢素滴眼剂对干眼患者泪液的影响[J].中国中医眼科杂志,2000,10(2):136. PANG Yaju, JIA Guiqin, FENG Jinling, et al. A study on effect of 0.5% cyclosporin A on tears of the patients with ophthalmoxerosis[J]. J Trad Chin Ophthalmol, 2000, 10(2):136. [5] 张汗承, 周祖廉, 赵成荣, 等. 干眼症记分分级和人工泪液疗效评价的研究[J]. 眼科研究, 1994, 12(1):25- 27. ZHANG Hancheng, ZHOU Zulian, ZHAO Chengrong, et al. Studies on scoring and grading the dry eye and evaluating the effect of artificial tears[J]. Chin Ophthal Res, 1994, 12(1):25- 27. [6] 江丹,刘新泉.秦皮滴眼液联合环孢素A 滴眼液治疗干眼症的疗效[J].国际眼科杂志,2013,13(10):2149-2150. JIANG Dan, LIU Xinquan. Research on dry eye syndrome cured with Qinpi and Cyclosporin A eyedrops[J]. Int Eye Sci, 2013, 13(10):2149-2150. [7] 罗丽辉,刘祖国,林建贤,等.干眼患者结膜上皮细胞的凋亡与炎症[J].中国眼耳鼻喉科杂志,2004,4(2):75. LUO Lihui, LIU Zuguo, LIN Jianxian, et al. The apoptosis and inflammation og conjunctival epithelium in dry eye patients[J]. Chin J Ophthalmal Otorhinolaryngol, 2004, 4(2):75-77. [8] Brignole F, Pisella P J, Goldschild M, et al. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes[J]. Invest Ophthalmol Vis Sci, 2000, 41(6):1356-1363. [9] Sall K N, Cohen S M, Christensen M T, et al. An evaluation of the efficacy of a cyclosporine based dry eye therapy when used with marketed artifical tears as supportive therapy in dry eye[J]. Eye Contact lens, 2006, 32(1):21. [10] Gao J, Schwalb T A, Addeo J V, et al. The role of apoptosis in the pathogenesis of canine kerato conjunctivitis sicca: the effect of topical cyclosporin A therapy[J]. Cornea, 1998, 17(6):654- 663. [11] Nussenblatt R B, Palestine A G, Chan C C, et al. Randomized, double-masked study of cyclosporine compared to prednisolone in the treatment of endogenous uveitis[J]. Am J Ophthalmol, 1991, 112(2):138-146. [12] Rao S N, Rao R D. Efficacy of Topical Cyclosporine 0.05% in the treatment of dry eye associated with graft versus host disease[J]. Cornea, 2006, 25(6):674-678. [13] Wilson S E, Perry H D. Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment[J]. Ophthalmology, 2007, 114(1):76-79. [14] Stevenson D, Tauber J, Reis B L. Efficacy and safety of cyclosporin A opthalmic emulsion in the treatment of moderate-to-severe dry eye disease: adose-ranging, randomized trial[J]. Ophthalmology, 2000, 107(5):967-974. [15] Gumus K, Cavanagh D H. The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca[J]. Clin Ophthalmol, 2009, 3:57-67. [16] 林碧娟,刘祖国,王小云,等.环孢素治疗中重度干眼症的对照研究[J].中山大学学报:医学科学版, 2006, 27(3):358-360. LIN Bijuan, LIU Zuguo, WANG Xiaoyun, et al. Controlled observation of Cyclosporine A in treatment of middle to severe dry eye[J]. J Sun Yat-sen Univ: Med Sci, 2006, 27(3):358-360. [17] 冯庆俊.环孢素A滴眼液治疗干眼症的疗效[J].实用医学杂志,2007,23(20):3268-3269. FEN Qingjun. The effects of Cyclosporine A in the treatment of dry eye syndrome[J]. J Practical Med, 2007, 23(20):3268-3269. |
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