ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 87-90.doi: 10.6040/j.issn.1673-3770.0.2015.483
张晓1,姜良柱1,2,徐艳云1,牟国营1
ZHANG Xiao1, JIANG Liangzhu1,2, XU Yanyun1, MU Guoying
摘要： 目的 观察等渗与低渗核黄素溶液进行角膜交联治疗圆锥角膜的疗效。 方法 将圆锥角膜患者根据治疗前角膜厚度分为两组,厚角膜组采用等渗核黄素溶液进行胶原交联,薄角膜组采用低渗核黄素溶液进行胶原交联。观察交联后两组患者角膜厚度、裸眼视力、矫正视力、顶点K值、角膜内皮细胞计数等指标。 结果 交联术后两年两组患者角膜厚度分别降低(11±14)μm(厚角膜组)、(7±9)μm(薄角膜组),差异有统计学意义;顶点K值分别降低(1.61±2.30)D(厚角膜组)、(2.58±3.22)D(薄角膜组),差异有统计学意义;两组裸眼视力、矫正视力均较治疗前有统计学意义提高;两组患者角膜内皮细胞计数治疗前后差异无统计学意义。 结论 交联可以有效控制圆锥角膜的进展,厚角膜患者可以采用等渗核黄素溶液进行胶原交联,薄角膜患者可以采用低渗核黄素溶液进行胶原交联。
中图分类号:
| [1] Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus[J]. Am J Ophthalmol, 2003, 135(5):620-627. [2] Hafezi F, Mrochen M, Iseli H P, et al. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas[J]. J Cataract Refractive Surgery, 2009, 35(4):621-624. [3] Dohlman C H, Anseth A. The swelling pressure of the ox corneal stroma[J]. Acta Ophthalmologica, 1957, 35(2):73-84. [4] Raiskup-Wolf F, Hoyer A, Spoerl E, et al. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus:long-term results[J]. J Cataract Refractive Surgery, 2008, 34(5):796-801. [5] Jankov M R, 2nd, Hafezi F, Beko M, et al. Corneal Cross-linking for the treatment of keratoconus: preliminary results[J]. Arq Bras Oftalmol, 2008, 71(6):813-818. [6] Muller L J, Pels E, Vrensen G F. The specific architecture of the anterior stroma accounts for maintenance of corneal curvature[J]. Br J Ophthalmol, 2001, 85(4):437-443. [7] Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line[J]. Cornea, 2006, 25(9):1057-1059. [8] Hafezi F. Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea[J]. Cornea, 2011, 30(8):917-919. [9] Goldich Y, Marcovich A L, Barkana Y, et al. Safety of corneal collagen cross-linking with UV-A and riboflavin in progressive keratoconus[J]. Cornea, 2010, 29(4):409-411. [10] Vinciguerra P, Albe E, Trazza S, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking[J]. Ophthalmology, 2009, 116(3):369-378. [11] Asri D, Touboul D, Fournie P, et al. Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus[J]. J Cataract Refractive Surgery, 2011, 37(12):2137-2143. [12] Hersh P S, Greenstein S A, Fry K L. Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results[J]. J Cataract Refractive Surgery, 2011, 37(1):149-160. [13] Vandelli M A, Rivasi F, Guerra P, et al. Gelatin microspheres crosslinked with D, L-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies[J]. Inter J Pharmaceutics, 2001, 215(1-2):175-184. [14] Ashar J N, Vadavalli P K. Long-term results of riboflavin ultraviolet A corneal collagen cross-linking for Keratoconus in Italy: the Siena eye cross study [J]. Am J Ophthalmol, 2010, 150(4):588; author reply -9. [15] Kanellopoulos A J, Asimellis G. Keratoconus management: long-term stability of topography-guided normalization combined with high-fluence CXL stabilization(the Athens Protocol)[J]. J Refractive Surgery(Thorofare, NJ:1995), 2014, 30(2):88-93. |
| [1] | 张春晓, 李志伟, 徐文文, 李凤娇, 陶祥臣, 牟国营. 核黄素/UVA诱导的角膜交联术治疗晚期圆锥角膜的安全性和有效性[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 86-88. |
| [2] | 胡 明,李招娜,李云杰,陶祥臣 . 硬性透气性角膜接触镜对圆锥角膜的塑形作用[J]. 山东大学耳鼻喉眼学报, 2007, 21(2): 171-173 . |
|