山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (1): 26-30.doi: 10.6040/j.issn.1673-3770.0.2015.489

• 论著 • 上一篇    下一篇

慢性鼻-鼻窦炎患者药物治疗的生存质量及相关研究

吴青松1,曾蓉1,刘明娜1,洪潮鑫2,刘绪光1,邓伟锋1,周凤平1   

  1. 深圳市龙岗区人民医院 1.耳鼻喉科 2.信息科, 广东 深圳 518172
  • 收稿日期:2015-11-18 出版日期:2016-02-16 发布日期:2016-02-16
  • 作者简介:吴青松. E-mail: 13798268398@139.com
  • 基金资助:
    深圳市科技计划项目(201203322);深圳市龙岗区科技局资助项目(YS2012085)

Investigation of quality of life on chronic rhinosinusitis following medication.

WU Qingsong1, ZENG Rong1, LIU Mingna1, HONG Chaoxin2, LIU Xuguang1, DENG Weifeng1, ZHOU Fengping1.   

  1. 1. Department of Otolaryngology, 2. Department of Information, Shenzhen Longgang Peoples Hospital, Shenzhen 518172, Guangdong, China
  • Received:2015-11-18 Online:2016-02-16 Published:2016-02-16

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摘要： 目的 使用鼻窦炎症状视觉模拟量表(VAS)及鼻窦炎专用量表-鼻腔鼻窦结局测试20(SNOT-20)中文版评价慢性鼻-鼻窦炎患者药物治疗前与治疗后不同时间的生存质量(QOL),探讨药物治疗对患者QOL的影响。 方法 收集慢性鼻-鼻窦炎患者100例作为实验组,给予药物联合治疗12周,每4周进行一次VAS评分及SNOT-20评分。另收集100例健康体检者作为对照组,进行一次相同的评分。分析实验组治疗前后及停药后患者VAS评分、SNOT-20评分的变化及与对照组的差异。 结果 实验组治疗前后及停药后VAS评分差异具有统计学意义(F=38.39,P<0.01)。实验组治疗12周后与对照组VAS评分比较差异具有统计学意义(t=7.93,P<0.01)。实验组VAS、CT评分于治疗后5个症状占比分别有所下降,每种症状的VAS、CT评分也有所下降。实验组治疗前后及停药后SNOT-20评分经单因素方差分析显示差异具有统计学意义(F=27.93,P<0.01)。实验组治疗12周后与对照组SNOT-20评分比较差异具有统计学意义(t=19.93,P<0.01)。实验组于治疗后各症状占比人数分别有所下降,每种症状的SNOT-20评分也有所下降。 结论 药物治疗作为慢性鼻-鼻窦炎的首选治疗方式,可有效改善患者的QOL,但长期小剂量使用的远期疗效尚有待进一步证实。

关键词: 生存质量, 慢性鼻-鼻窦炎, 药物治疗

Abstract: Objective To evaluate chronic rhino-sinusitis medication before treatment and quality of life(QOL)at different times after treatment and to investigate the drug therapy on QOL of patients. Methods Using sinusitis symptom visual analog scale(VAS)and sinusitis special scale-sinonasal outcome Test 20(SNOT-20), we collect 100 patients with chronic rhinitis-sinusitis as the experimental group receiving 12 weeks combination therapy drugs, once every four weeks, and another 100 healthy volunteers as the control group. Results By univariate analysis, the VAS score showed a significant difference(F=38.39, P<0.01)before and after treatment in the experimental group, and it showed a significant difference(t=7.93, P<0.01)between the 12-week after treatment group and the control group; After the drug treatment, VAS and CT score of 5 symptoms accounted decreases and each symptom rate also declined. By univariate analysis, the SNOT-20 score also showed a significant difference(F=27.93, P<0.01)before and after treatment in the experimental group, and it showed a significant difference(t=19.93, P<0.01)between the 12-week after treatment group and the control group;After the drug treatment, patents with each symptom accounted decrease and each symptom rate also declined. Conclusion Drug treatment can effectively improve the QOL chronic rhinitis sinusitis, whether needing long-term low-dose use remains further confirmation.

Key words: Chronic rhinitis-sinusitis, Quality of life, Medication

中图分类号: 

  • R765.4
[1] 袁海,韩爱国,白晓明,等.慢性鼻-鼻窦炎鼻息肉药物治疗进展概述[J].临床耳鼻咽喉头颈外科杂志,2011,25(8):382-384.
[2] Hissaria P, Smith W, Wormald P J, et al. Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures[J].J Allergy Clin Immunol, 2006, 118(1):128-133.
[3] Fokkens W J, Lund V J, Mullol J, et al. European position paper on rhinosinusitis and nasal polyps 2012[J]. Rhinol Suppl, 2012, 5(23):1-298.
[4] 中华医学会耳鼻咽喉头颈外科分会鼻科组,中华耳鼻咽喉头颈外科杂志编委会.慢性鼻-鼻窦炎诊断和治疗指南(2008年,南昌)[J].中华耳鼻咽喉头颈外科杂志,2009,44(1):6-7.
[5] 左可军,方积乾,Piccirillo J F,等.鼻腔鼻窦结局测试-20(SNOT-20)量表中文版的研制[J].中华耳鼻咽喉头颈外科杂志,2008,43(10):751-756. ZUO Kejun, FANG Jiqian, Piccirillo J F, et al. Development of the sino-nasal outcome test-20 Chinese version(SNOT-20 CV)[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2008, 43(10):751-756.
[6] Melen I. Chronic sinusitis: clinical and pathophysiological aspects[J].Acta Otolaryngol Suppl, 1994, 515(1):45-48.
[7] Blackwell D C J, Coles R. Summary health statistics for US adults: National Health Interview Survey 1997. National Center for Health Statistics[J]. Vital Health Stat, 2002, 205:1-109.
[8] Zhang L, Han D, Huang D, et al. Prevalence of self-reported allergic rhinitis in eleven major cities in china[J]. Int Arch Allergy Immunol, 2009, 149(1):47-57.
[9] Fokkens W, Lund V, Mullol J, et al. European position paper on rhinosinusitis and nasal polyps 2007[J].Rhinol Suppl, 2007(20):1-136.
[10] Wallwork B, Coman W, Mackay-Sim A, et al. A double-blind,randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis[J].Laryngoscope, 2006, 116(2):189-193.
[11] Verret D J, Marple B F. Effect of topical nasal steroid sprays on nasal mucosa and ciliary function[J].Curr Opin Otolaryngol Head Neck Surg, 2005, 13(1):14-18.
[12] Yamada T, Fujieda S, Mori S, et al.Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage[J]. Am J Rhinol, 2000, 14(3):143-148.
[13] Luo Q, Chen F, Liu W, et al. Nasal Health Group, China(NHGC).Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps[J]. ORL J Otorhinolaryngol Relat Spec, 2011, 73(4):206-211.
[14] 迪丽达尔,王德辉,史丽,等.加强药物治疗与功能性内镜鼻窦手术+围手术期综合治疗慢性鼻-鼻窦炎疗效的多中心对照研究[J].中华耳鼻咽喉头颈外科杂志,2013,48(9):734-740. Dilidaer, WANG Dehui, SHI Li, et al. A prospective multicenter clinical trial of medical and surgical treatment for chronic rhinosinusitis[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2013, 48(9):734-740.
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