山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (5): 198-205.doi: 10.6040/j.issn.1673-3770.0.2022.279
• 综述 • 上一篇
黄艳利1,2,李军政1,3
HUANG Yanli1,2, LI Junzheng1,3
摘要: 铜是人体必不可少的微量元素之一,在多种基本生物学功能中起着关键作用,并且受到铜伴侣蛋白及铜转运蛋白的严格调控。铜在肿瘤生长、上皮-间充质转化、肿瘤微环境和转移前生态位的形成中发挥重要作用,因此铜稳态的失衡可影响肿瘤细胞的生长,导致细胞死亡。铜可通过多种方式诱导肿瘤细胞死亡,如诱导活性氧催化氧化应激、抑制泛素-蛋白酶体系统、肿瘤血管的生成受到抑制等,而新近发现的一种新的调节性细胞死亡方式即“铜死亡”与以往已知的细胞死亡机制都有所不同。因此,铜诱导的调节性细胞死亡机制引起了人们的极大关注,并成为肿瘤治疗领域的研究热点。论文综述铜诱导肿瘤细胞死亡机制的研究进展,并回顾铜诱导肿瘤细胞死亡在乳腺癌、结直肠癌、肺癌、前列腺癌等各种肿瘤治疗中的研究进展。
中图分类号:
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