山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (1): 92-100.doi: 10.6040/j.issn.1673-3770.0.2022.541
宋斐1,2,宋昊1,2,李玉梅2,牟亚魁2,宋西成2
SONG Fei1,2, SONG Hao1,2, LI Yumei2, MOU Yakui2, SONG Xicheng2
摘要: 头颈鳞状细胞癌是最常见的恶性肿瘤之一,肿瘤源性外泌体可通过直接与细胞受体相互作用或与质膜发生质膜融合参与免疫细胞调控,在头颈鳞状细胞癌的调控中发挥作用。肿瘤源性外泌体不仅可以抑制杀伤性免疫细胞对肿瘤的杀伤作用,还可以负向调节免疫抑制性细胞,促进肿瘤细胞发生免疫逃逸,以此调控肿瘤发生、发展以及远处转移。论文综述肿瘤源性外泌体在头颈鳞状细胞癌微环境中调控不同类型免疫细胞的研究进展。通过研究肿瘤源性外泌体在肿瘤微环境中的调控作用,为实现外泌体递药、肿瘤靶向治疗提供新策略。
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