山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 13-17.doi: 10.6040/j.issn.1673-3770.0.2023.044

• 论著 • 上一篇    下一篇

疫苗相关性葡萄膜炎的临床特征分析:基于美国疫苗不良事件报告系统的回顾性研究

侯宁1,杨军兴2,张宇鹏1,林子淳1,邓爱军2   

  1. 临床医学院), 山东第二医科大学, 山东 潍坊 261000;
    2. 山东第二医科大学附属医院 眼科中心, 山东 潍坊 261000
  • 出版日期:2024-03-20 发布日期:2024-03-29
  • 通讯作者: 邓爱军. E-mail:dengaijun@hotmail.com

Analysis of clinical characteristics of vaccine-associated uveitis: a retrospective study based on American vaccine adverse event reporting system

HOU Ning1, YANG Junxing2, ZHANG Yupeng1, LIN Zichun1, DENG Aijun2   

  1. 1. Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang 261000, Shandong, China2. Ophthalmic Center, Affiliated Hospital of Shandong Second Medical University, Weifang 261000, Shandong, China
  • Online:2024-03-20 Published:2024-03-29

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摘要： 目的 了解疫苗相关性葡萄膜炎的临床特征,为疫苗安全性监测、预防接种以及临床诊治提供参考。 方法 通过美国疫苗不良事件报告系统收集1990—2022年所有接种疫苗后发生葡萄膜炎的相关报告,并对接种者的性别、年龄、接种疫苗类型、疫苗剂次、葡萄膜炎发生时间以及葡萄膜炎类型进行回顾性分析。 结果 317例疫苗相关性葡萄膜炎病例中,共涉及10余种疫苗类型,主要为COVID-19疫苗、人乳头瘤病毒疫苗、乙型肝炎疫苗。男86例、女231例,男女比例为1∶2.7。18~<60岁接种者发生葡萄膜炎最多,占比65.3%。葡萄膜炎常见于接种疫苗后<8 d和第1剂疫苗接种后发生,分别占比56.8%和47.0%。184例葡萄膜炎类型分组报告中,虹膜睫状体炎占比最高,为56.5%。 结论 充分认识、深入研究接种疫苗的这一不良反应,持续开展疫苗安全性监测,更好进行预防接种以及临床诊治。

关键词: 疫苗, 葡萄膜炎, 疫苗不良事件报告系统, 不良反应

Abstract: Objective To investigate the clinical characteristics of vaccine-associated uveitis in order to provide a reference for vaccine safety monitoring, vaccination, and clinical diagnosis and treatment. Methods The vaccine-associated uveitis reports from 1990 to 2022 were collected from the American Vaccine Adverse Event Reporting System. Moreover, sex, age, type of vaccination, dose series, time of occurrence, and type of uveitis of vaccine-associated uveitis reports were retrospectively analyzed. Results Of the 317 cases of vaccine-associated uveitis, more than 10 types of vaccine were involved, mainly the COVID-19 vaccine, human papillomavirus vaccine, and hepatitis B vaccine. There were 86 males and 231 females, with a male-to-female ratio of 1:2.7. Patients aged 18-<60 years, accounted for the majority of the total cases(65.3%). Uveitis is common under 8 days after vaccination and after the first dose of vaccination, accounting for 56.8% and 47.0%, respectively. Iridocyclitis represented the highest proportion of 184(56.5%)cases of uveitis. Conclusion Fully understand and study this adverse reaction to vaccination in depth, continue to monitor vaccine safety, better vaccination, and clinical diagnosis and treatment.

Key words: Vaccine, Uveitis, Vaccine adverse event reporting system, Adverse reaction

中图分类号: 

  • R773
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