山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (4): 121-125.doi: 10.6040/j.issn.1673-3770.0.2023.238

• 论著 • 上一篇    

3D打印钛金属假体修复大面积气管缺损1例并文献复习

汪洋1,胡越1,2,李晓明3,齐雯雯1,张杰1,张皓1,王倩倩1,许风雷3,贾涛1,夏明3   

  1. 1.山东大学第二医院 耳鼻咽喉头颈外科, 山东 济南 250033;
    2.山东大学齐鲁医学院, 山东 济南 250012;
    3.山东第一医科大学附属山东省立医院 耳鼻咽喉头颈外科, 山东 济南 250021
  • 发布日期:2024-07-09
  • 通讯作者: 贾涛. E-mail:jiatao@sdu.edu.cn; 夏明. E-mail:xiaming0913@sohu.com

Three-dimensionally printed titanium prosthesis for repair of large tracheal defect: a case report and literature review

WANG Yang1, HU Yue1,2, LI Xiaoming3, QI Wenwen1, ZHANG Jie1, ZHANG Hao1, WANG Qianqian1, XU Fenglei3, JIA Tao1, XIA Ming3   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China 2. College of Medicine, Shandong University, Jinan 250012, Shandong, China 3. Department of Otorhinolaryngology & Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2024-07-09

PDF (PC)

52

摘要： 目的 探讨大气管缺损的发病机制、诊断依据、治疗方法。 方法 回顾性分析1例采用3D打印钛金属假体修复纵隔肿瘤占位大面积气管缺损患者的临床资料并复习相关文献进行总结。 结果 大面积气管缺损修复一直是临床上的难题,采用3D打印钛金属气管假体进行气管缺损的修复可个性化还原患者气管正常生理结构,拥有较稳固的力学性能,可有效防止气道塌陷的情况,预设计的个体化定制的气管假体更贴合患者,可缩短手术时间,减少患者术后并发症。 结论 在大面积气管缺损患者的治疗中,相较于传统的修补方法,采用3D打印钛金属气管假体进行气管缺损的修复显示出了更大的优势,为大面积气管缺损的患者带来了治疗曙光。

关键词: 大面积气管缺损, 3D打印, 气管假体, 纵隔肿瘤

Abstract: Objective This study aimed to explore the pathogenesis, diagnostic criteria, and treatments for tracheal defects. Methods We retrospectively analyzed the clinical data of a patient with a large tracheal defect caused by a mediastinal tumor using a three-dimensionally(3D)printed titanium prosthesis and summarizing relevant literature. Results Repairing large tracheal defects has always been a clinical challenge. Using 3D-printed titanium tracheal prostheses for tracheal defect repair can personalize and restore a patient's normal physiological structure and have stable mechanical properties. Prosthesis use can effectively prevent airway collapse, and its pre-designed customized shape fits the patient better, shortening operation time and reducing postoperative complications. Conclusion In the treatment of large tracheal defects, 3D-printed titanium tracheal prostheses have greater advantages than traditional repair methods, bringing new hope for patients with large tracheal defects.

Key words: Large area tracheal defect, 3D-printing, Tracheal prosthesis, Mediastinal tumor

中图分类号: 

  • R762
[1] Xia DK, Jin DW, Wang Q, et al. Tissue-engineered trachea from a 3D-printed scaffold enhances whole-segment tracheal repair in a goat model[J]. J Tissue Eng Regen Med, 2019, 13(4): 694-703. doi:10.1002/term.2828
[2] Wang SM, Zhang HB, Zhu LM, et al. Surgical management of congenital tracheal stenosis associated with tracheal bronchus and congenital heart disease[J]. Eur J Cardiothorac Surg, 2016, 49(4): 1201-1206. doi:10.1093/ejcts/ezv317
[3] Ott LM, Zabel TA, Walker NK, et al. Mechanical evaluation of gradient electrospun scaffolds with 3D printed ring reinforcements for tracheal defect repair[J]. Biomed Mater, 2016, 11(2): 025020. doi:10.1088/1748-6041/11/2/025020
[4] Delaere P, Vranckx J, Verleden G, et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy[J]. N Engl J Med, 2010, 362(2): 138-145. doi:10.1056/NEJMoa0810653
[5] Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway[J]. Lancet, 2008, 372(9655): 2023-2030. doi:10.1016/S0140-6736(08)61598-6
[6] Liu J, Lu D, Deng D, et al. Free posterior tibial artery perforator flap for 2-stage tracheal reconstruction in patients after resection of well-differentiated thyroid carcinoma invading the trachea[J]. Head Neck, 2019, 41(7): 2249-2255. doi:10.1002/hed.25675
[7] 邓迪, 刘均, 李林珂, 等. 皮瓣二期重建策略应用于气管非环周缺损修复重建[J]. 山东大学耳鼻喉眼学报, 2020, 34(3): 52-57. doi: 10.6040/j.issn.1673-3770.1.2020.032 DENG Di, LIU Jun, LI Linke, et al. Two-stage reconstructive strategy using a flap for non-circumferential tracheal defects[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 52-57. doi: 10.6040/j.issn.1673-3770.1.2020.032
[8] Tsukada H, Osada H. Experimental study of a new tracheal prosthesis: pored Dacron tube[J]. J Thorac Cardiovasc Surg, 2004, 127(3): 877-884. doi:10.1016/s0022-5223(03)01317-5
[9] 曹子昂, 顾旭东, 林海平, 等. 自体心包包裹人工气管修复气管缺损的组织相容性评估[J]. 中国组织工程研究与临床康复, 2008, 12(14): 2645-2647. doi:10.3321/j.issn: 1673-8225.2008.14.024 CAO Ziang, GU Xudong, LIN Haiping, et al. Histocompatibility of autologous pericardium-covered tracheal prosthesis to repair tracheal defect[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2008, 12(14): 2645-2647. doi:10.3321/j.issn: 1673-8225.2008.14.024
[10] Kubo T, Kurita T, Tashima H, et al. Immediate tracheal reconstruction with forearm flap and bone graft[J]. Microsurgery, 2019, 39(1): 46-52. doi:10.1002/micr.30365
[11] 张生军, 王启荣, 梁辉, 等. 喉气管狭窄的手术治疗[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 77-82.doi: 10.6040/j.issn.1673-3770.0.2016.433 ZHANG Shengjun, WANG Qirong, LIANG Hui, et al. Surgical treatment of laryngotracheal stenosis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(2): 77-82.doi: 10.6040/j.issn.1673-3770.0.2016.433
[12] Chang JW, Park SA, Park JK, et al. Tissue-engineered tracheal reconstruction using three-dimensionally printed artificial tracheal graft: preliminary report[J]. Artif Organs, 2014, 38(6): E95-E105. doi:10.1111/aor.12310
[13] She Y, Fan Z, Wang L, et al. 3D Printed biomimetic pcl scaffold as framework interspersed with collagen for long segment tracheal replacement[J]. Front Cell Dev Biol, 2021, 9: 629796. doi: 10.3389/fcell.2021.629796
[14] Ott LM, Zabel TA, Walker NK, et al. Mechanical evaluation of gradient electrospun scaffolds with 3D printed ring reinforcements for tracheal defect repair[J]. Biomed Mater, 2016, 11(2): 025020. doi:10.1088/1748-6041/11/2/025020
[15] Ahn HJ, Khalmuratova R, Park SA, et al. Serial analysis of tracheal restenosis after 3D-printed scaffold implantation: recruited inflammatory cells and associated tissue changes[J]. Tissue Eng Regen Med, 2017, 14(5): 631-639. doi:10.1007/s13770-017-0057-y
[16] Park JH, Hong JM, Ju YM, et al. A novel tissue-engineered trachea with a mechanical behavior similar to native trachea[J]. Biomaterials, 2015, 62: 106-115. doi: 10.1016/j.biomaterials.2015.05.008
[17] Jung SY, Lee SJ, Kim HY, et al. 3D printed polyurethane prosthesis for partial tracheal reconstruction: a pilot animal study[J]. Biofabrication, 2016, 8(4): 045015. doi:10.1088/1758-5090/8/4/045015
[18] Kang Y, Wang CL, Qiao YB, et al. Tissue-engineered Trachea consisting of electrospun patterned sc-PLA/GO- g-IL fibrous membranes with antibacterial property and 3D-printed skeletons with elasticity[J]. Biomacromolecules, 2019, 20(4): 1765-1776. doi:10.1021/acs.biomac.9b00160
[19] Lee HY, Lee JW. Current status and future outlook of additive manufacturing technologies for the reconstruction of the Trachea[J]. J Funct Biomater, 2023, 14(4): 196. doi:10.3390/jfb14040196
[20] 王艳杰, 程冯丽. 3D打印技术应用于耳鼻咽喉科临床前瞻创新[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 114-118. doi:10.6040/j.issn.1673-3770.0.2019.538 WANG Yanjie, CHENG Fengli. Latest research progress of 3D printing technology and clinical applications in otorhinolaryngology[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 114-118. doi:10.6040/j.issn.1673-3770.0.2019.538
[1] 程熹乔,瞿申红. 3D打印技术在鼻科学的应用及进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 128-136.
[2] 王艳杰,程冯丽,赵长青. 3D打印技术应用于耳鼻咽喉科临床前瞻创新[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 114-118.
[3] 郭颖媛,张德军,管国芳,文连姬,张辉,于多娇,马帅帅. 3D打印技术在耳鼻喉科住院医师规范化培训中的应用探索[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 119-122.
[4] 吴昆旻,吴建,李泽卿,陈伟,朱春晖,杨祁. 3D打印辅助上颌骨切除术后缺损重建[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 29-32.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发