山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 113-121.doi: 10.6040/j.issn.1673-3770.0.2023.263

• 综述 • 上一篇    下一篇

感音神经性聋的代谢组学研究进展

杨旻,朱晓燕,王旭   

  1. 南京中医药大学附属南京市中西医结合医院 耳鼻喉科, 江苏 南京 210014
  • 出版日期:2024-03-20 发布日期:2024-03-29
  • 通讯作者: 王旭. E-mail:wangxu830@163.com

Progress in metabolomics research in sensorineural hearing loss

YANG Min, ZHU Xiaoyan, WANG Xu   

  1. Department of Otorhinolaryngology, Nanjing University of Traditional Chinese Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing 210014, Jiangsu, China
  • Online:2024-03-20 Published:2024-03-29

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14

摘要： 感音神经性聋是耳科临床常见的疾病,是耳蜗、听神经或听觉中枢器质性病变导致的听力损失,其发病与遗传、年龄、噪声暴露、耳毒性药物等多种因素相关,目前发病率逐年上升且呈现年轻化的趋势。代谢组学是通过采用高通量组学技术对所有代谢物进行鉴定和定量的生命科学研究,近年来在内耳病理生理机制研究中有一定的应用,代谢组学从代谢改变的视角提供了病因探索的新思路,其研究问题包括分析代谢物与感音神经性聋的关联、发现新型代谢标志物、寻找防治感音神经性聋的新策略等。代谢组学在感音神经性聋方面的应用有助于感音神经性聋的早期诊断、个体化治疗和预测其预后。论文综述了感音神经性聋的代谢组学国内外研究进展,对临床试验、动物实验的方法和结果进行了整合和分析,以期为感音神经性聋代谢组学的研究和临床应用提供依据,并提出展望。

关键词: 感音神经性聋, 代谢组学, 综述, 代谢标志物

Abstract: Sensorineural hearing loss is a common clinical disease in otology, which is hearing loss or hearing loss caused by cochlea, auditory nerve or auditory center organic lesions, and its incidence is related to genetics, age, noise exposure, ototoxic drugs and other factors, and the current incidence is increasing year by year and showing a younger trend. Metabolomics is a life science research that uses high-throughput omics technology to identify and quantify all metabolites, and has been applied to the pathophysiological mechanism of the inner ear in recent years, metabolomics provides new ideas for etiological exploration from the perspective of metabolic changes, and its research problems include analyzing the association between metabolites and sensorineural hearing loss, discovering new metabolic markers, and finding new strategies for preventing and treating sensorineural hearing loss. The application of metabolomics in sensorineural hearing loss contributes to the early diagnosis, individualized treatment and prediction of sensorineural hearing loss. In this paper, the research progress of metabolomics of sensorineural hearing loss is reviewed at home and abroad, and the experimental methods and results of clinical trials and animal experiments are integrated and analyzed, in order to provide a basis for the research and clinical application of metabolomics of sensorineural hearing loss, and put forward a prospect.

Key words: Sensorineural hearing loss, Metabolomics, Review, Biomarkers

中图分类号: 

  • R764.43
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