山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (6): 23-29.doi: 10.6040/j.issn.1673-3770.0.2023.489

• 研究进展 • 上一篇    

咽喉反流性疾病在常见呼吸道疾病中的作用

张利,张梦茹,阿丽米热·艾尔肯,邱忠民   

  1. 同济大学附属同济医院 呼吸与危重症医学科, 上海 200065
  • 发布日期:2024-12-13
  • 通讯作者: 邱忠民. E-mail:qiuzhongmin@tongji.edu.cn
  • 基金资助:
    上海市科委课题(20Y11902500,21140903400)

Role of pharyngeal reflux in common respiratory diseases

ZHANG Li, ZHANG Mengru, Alimire Aierken, QIU Zhongmin   

  1. Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
  • Published:2024-12-13

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摘要： 咽喉反流(laryngopharyngeal reflux, LPR)是胃食管反流病的一种食管外表现形式,涉及多学科疾病,临床表现多变且缺乏特异性,其确切的发病机制尚不明确。消化道(胃、食管等)与呼吸道毗邻,有共同的前肠胚胎起源和迷走神经支配,两者通过食管-气管支气管反射或气管支气管-食管反射密切联系,相互影响。LPR是上、下呼吸道气道炎症的潜在促发因素,与多种呼吸道疾病(如慢性咳嗽、慢性鼻-鼻窦炎、哮喘、慢性阻塞性肺病、阻塞性睡眠呼吸暂停低通气综合征、特发性肺纤维化等)相关。在临床实践中治疗伴有LPR的呼吸系统疾病患者时应考虑多种疗法联合治疗,为患者提供个体化治疗方案。论文就LPR在常见呼吸道疾病中的作用进行综述。

关键词: 咽喉反流, 胃食管反流, 迷走神经, 呼吸道, 抗反流

Abstract: Laryngopharyngeal reflux(LPR)is an extraesophageal manifestation of gastroesophageal reflux disease(GERD), involving multiple disciplines, with variable and nonspecific clinical presentations, and its exact pathogenesis remains unclear. The gastrointestinal tract(stomach, oesophagus, etc.)is adjacent to the respiratory tract, sharing a common foregut embryonic origin and vagal innervation. The two are closely linked by the oesophago-tracheobronchial or tracheobronchial-esophageal reflex and influence each other. LPR is a potential precipitating factor for upper and lower airway inflammation and is associated with several respiratory diseases(e.g. chronic cough, chronic rhinosinusitis, asthma, obstructive sleep apnoea-hypopnoea syndrome, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis). In clinical practice, the management of patients with respiratory diseases associated with LPR should consider a combination of therapeutic approaches to provide individualized treatment plans for patients. This article provides an overview of the role of LPR in common respiratory diseases.

Key words: Laryngopharyngeal reflux, Gastroesophageal reflux, Vagal nerve, Respiratory tract, Anti-reflux

中图分类号: 

  • R766.5
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