山东大学耳鼻喉眼学报 ›› 2026, Vol. 40 ›› Issue (1): 135-141.doi: 10.6040/j.issn.1673-3770.0.2024.029

• 综述 • 上一篇    

外泌体在眼病发病机制和诊疗中的研究进展

刘一洁1,卢秀珍1,2,吴秋欣1,2   

  1. 1.山东中医药大学 第一临床医学院, 山东 济南 250014 ;
    2.山东中医药大学附属眼科医院眼科 /山东省眼病防治研究院/山东省中西医结合眼病防治重点实验室 斜弱视科, 山东 济南 250002
  • 发布日期:2026-02-13
  • 基金资助:
    国家自然科学基金(82104937);国家重点研发计划项目(2021YFC2702103,2021YFC2702100,2021YFC2702104);山东省中医药科技项目(M-2023010);山东省中西医结合专病防治项目(YXH2019ZXY001)

Research rogress of exosomes in the pathogenesis, diagnosis and treatment in ophthalmic diseases

LIU Yijie1, LU Xiuzhen1,2, WU Qiuxin1,2   

  1. 1. First Clinical Meidical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China2. Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine/Shandong Academy of Eye Disease Prevention and Therapy/Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Jinan 250002, Shandong, China
  • Published:2026-02-13

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11

摘要： 外泌体是由多种活细胞分泌的纳米级细胞外囊泡,具有脂质双层膜结构,广泛存在于各种体液当中。外泌体在细胞间的信息交流、免疫反应、修复再生等方面发挥重要作用,不同来源的外泌体功能不尽相同。近年来,外泌体在眼科疾病的诊断、治疗、预后评估中均取得了一定的进展,使眼病个性化治疗成为可能,并为眼病治疗方式的选择提供依据。本文就外泌体在眼病发病机制、诊断、治疗方面的研究进展作一综述。

关键词: 外泌体, 眼病, 发病机制, 诊断, 治疗

Abstract: Exosomes are nanoscale extracellular vesicles secreted by a variety of living cells. They have a lipid bilayer membrane structure and are widely distributed in various body fluids. They play an important role in information exchange between cells, immune response, repair and regeneration, etc. Exosomes from different sources have different functions. In recent years exosomes have shown great research potential in the diagnosis, treatment and prognosis evaluation of eye diseases, which may lead to more personalised treatment for patients with eye diseases and provide a basis for the selection of treatment methods for eye diseases. This article reviews the role of exosomes in the pathogenesis, diagnosis, and treatment of ophthalmic diseases.

Key words: Exosomes, Ophthalmic diseases, Pathogenesis, Diagnosis, Treatment

中图分类号: 

  • R77
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