年龄相关性听力损失患者前扣带回神经递质水平及其与听力水平关系的初步研究

doi:10.6040/j.issn.1673-3770.0.2024.242

摘要/Abstract

摘要： 目的初步探究年龄相关性听力损失患者的前扣带回(anterior cingulate cortex,ACC)是否存在神经递质改变。方法本研究纳入年龄相关性听力损失(age-related hearing loss, ARHL)患者8例,匹配相当年龄、性别等一般资料的听力正常(normal hearing, NH)老年人8例作为对照组。采用纯音听阈测试评估所有受试者0.25、0.5、1、2、4及8 kHz的听力水平。采用磁共振波谱(magnetic resonance spectroscopy, MRS)技术测定两组受试者ACC的γ-氨基丁酸(γ-aminobutyric acid, GABA)和谷氨酸盐-谷氨酰胺(glutamine and glutamate, GLx)水平。应用SPSS 27.0对数据进行统计分析。结果 ARHL组相比NH组GABA水平下降(P=0.021)、GLx水平升高(P<0.001),GABA水平与8 kHz纯音听阈呈显著负相关(P=0.014),Glx水平与0.5、1.0、2.0、4.0和8.0 kHz纯音听阈均呈正相关(P<0.05)。结论年龄相关性听力损失患者前扣带回神经递质存在紊乱,且与听力损失程度及频率相关,这为探索ARHL相关脑区的分子水平改变提供了参考。

Abstract: Objective This study aims to explore whether ARHL is related to the ACC from the perspective of neurotransmitter levels, thereby providing experimental evidence for understanding the mechanisms of ARHL. Methods The study included 8 ARHL patients, 8 age-matched, gender-matched normal hearing(NH)elderly individuals were recruited as the control group. Pure-tone audiometry was used to assess the hearing levels of all subjects at 0.25, 0.5, 1, 2, 4, and 8 kHz. Magnetic resonance spectroscopy(MRS)was employed to measure γ-aminobutyric acid(GABA)and glutamine-glutamate(Glx)levels in the ACC of both groups. Data were statistically analyzed using SPSS v27.0. Results Compared to the NH group, the ARHL group showed significantly lower GABA levels(P=0.021)and significantly higher Glx levels(P<0.001). GABA levels were significantly negatively correlated with 8 kHz pure-tone thresholds(P=0.014), and Glx levels were significantly positively correlated with pure-tone thresholds at 0.5, 1, 2, 4, and 8 kHz(all P<0.05). Conclusion Neurotransmitter dysregulation in the ACC of ARHL patients is associated with the degree and frequency of hearing loss, which may provide a theoretical basis for future research on the mechanisms underlying ARHL.

Key words: Age-related hearing loss, Anterior cingulate cortex, γ-aminobutyric acid, Glutamate-glutamine, Hearing level

中图分类号:

R764.43+6

陶朵朵,史彬,赵云舒,李勇刚,刘济生. 年龄相关性听力损失患者前扣带回神经递质水平及其与听力水平关系的初步研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 31-39.

TAO Duoduo, SHI Bin, ZHAO Yunshu, LI Yonggang, LIU Jisheng. Preliminary study on neurotransmitter levels in the anterior cingulate cortex and their relationship with hearing levels in patients with age-related hearing loss[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 31-39.

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