原发性鼻腔高级别非肠型腺癌1例并文献复习

doi:10.6040/j.issn.1673-3770.0.2024.375

摘要/Abstract

摘要： 目的探讨鼻腔鼻窦非肠型腺癌的临床病理特征、诊断和治疗方法。方法回顾分析1例鼻腔高级别非肠型腺癌患儿的临床表现、影像学、病理学及随访资料,同时结合文献总结鼻腔鼻窦非肠型腺癌的诊疗思路及预后。结果患者经鼻内镜行左侧鼻腔肿物切除术+鼻窦开放术,术后病理示鼻腔恶性肿瘤,免疫组化示CK7阳性,CK20、CDX2、S0X10阴性,随访患者未见复发。结论鼻腔鼻窦高级别非肠型腺癌罕见,病理活检是诊断的金标准;治疗手段主要为手术彻底切除,切缘阴性是影响预后的关键因素。

关键词: 鼻腔肿瘤, 高级别非肠型腺癌, 腺癌, 病理特征, 预后

Abstract: Objective To explore the clinicopathological characteristics, diagnosis, and therapies of non-intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Methods Retrospectively analyzed the clinical presentation, imaging manifestations, pathological findings, and follow-up data of a pediatric case of high-grade NITA. Summarize the diagnosis and treatment strategies, as well as the prognosis of NITA of the nasal cavity and paranasal sinuses, based on literature reviews. Results The patient underwent tumor resection of the left nasal cavity + sinus opening surgery by nasal endoscopy. Postoperative pathology confirmed a malignant nasal cavity tumor, immunohistochemistry showing positivity for CK7 and negativity for CK20, CDX2 and SOX10. No recurrence was observed during follow-up. Conclusion High-grade NITA of the nasal cavity and paranasal sinuses is rare, and pathological biopsy remains the gold standard for diagnosis. Complete surgical resection with negative margins is the primary treatment, and the state of the margins is a critical prognostic factor.

Key words: Nasal cavity neoplasms, High-grade non-intestinal-type adenocarcinoma, Adenocarcinoma, Pathological characteristics, Prognosis

中图分类号:

R739.62

彭中华,陈竹,袁洛花,余绍兰,马玉玲. 原发性鼻腔高级别非肠型腺癌1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 95-98.

PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling. Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 95-98.

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