口咽部鳞状细胞癌与性行为和人乳头状瘤病毒感染

doi:10.6040/j.issn.1673-3770.1.2012.015

山东大学耳鼻喉眼学报 ›› 2013, Vol. 27 ›› Issue (1): 1-7.doi: 10.6040/j.issn.1673-3770.1.2012.015

• 名医笔谈 • 下一篇

口咽部鳞状细胞癌与性行为和人乳头状瘤病毒感染

李国俊1,2，潘新良3，雷大鹏3，陈兴明4，陈晓红5，宋西成6

1.头颈外科系； 2.分子流行病学系，美国德克萨斯大学MD Anderson癌症中心，休斯顿，德克萨斯，77030；
3.山东大学齐鲁医院耳鼻咽喉头颈外科，济南 250012； 4.北京协和医院耳鼻咽喉头颈外科，北京 100730；
5.北京同仁医院耳鼻咽喉头颈外科，北京 100730；
6.青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东烟台 264000

收稿日期:2012-12-12 发布日期:2013-02-16

Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx

Guojun Li1,2, MD, PhD, Xinliang Pan3, MD, PhD, Dapeng Lei3, MD, PhD, Xingming Chen4, MD, PhD, Xiaohong Chen5, MD, PHD, Xicheng Song6, MD, PhD

1. Department of Head and Neck Surgery; 2. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030; 3. Department of Otolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University; Key Laboratory of Otolaryngology, Ministry of Health, P.R.China, Jinan 250012, China; 4. Department of Otolaryngology & Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; 5. Department of Otolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 6. Department of Otorhinolaryngology & Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China

Received:2012-12-12 Published:2013-02-16
Contact: Guojun Li, MD, PhD, Department of Head and Neck Surgery, Unit 1445, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030;Tel: (713) 792-0227

摘要/Abstract

摘要：

高危型人乳头状瘤病毒感染(high risk human papillomavirus, HR HPV)是头颈部鳞状细胞癌发生的一个重要相关因素，特别是原发口咽部、缺少烟酒等危险因素的患者。口咽肿瘤中确认发现HR HPV，以及流行病学病例对照研究明确HR HPV与口咽癌发病风险的关系，已阐明了二者的联系。重点论述口咽癌患者与非口咽癌患者在口腔、喉腔和下咽部位的比较及性行为方式的影响。明确头颈肿瘤的性行为危险因素对未来肿瘤预防是必不可少的，同时以利于理解现有的HPV疫苗对未来头颈肿瘤预防的潜在作用。同时还扩展到性行为作为口咽癌发生的一个危险因素以及其作为HPV暴露标记的作用，强调HR HPV是通过性行为传播到上呼吸消化道，增加HPV相关的口咽癌的发病风险。

关键词: 高危型人乳头状瘤病毒, 头颈部鳞状细胞癌, 性行为

Abstract:

High risk human papillomavirus (HR HPV) infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol. The link between HR HPV and carcionoma of the oropharynx have been suggested based on the identification of HR HPV in oropharyngeal tumors and association of HR HPV with the risk of oropharyngeal cancer from casecontrol epidemiologic studies. This review highlights the roles of sexual behavior characteristics in patients with oropharyngeal cancer compared with patients with non-oropharyngeal cancers at sites of oral cavity, larynx, and hypopharynx. Determining the behavioral risk factors for head and neck cancer is imperative for future cancer prevention efforts and for understanding the potential role of the HPV vaccine currently available. This review also expands our understanding of the roles of sexual behavior as a risk factor for oropharyngeal cancer and its role as a marker of HPV exposure and emphasizes that HR HPV is sexually transmitted to the upper aerodigestive tract and that certain sexual behaviors increase the risk for HPV-associated oropharyngeal cancer.

Key words: High risk human papillomavirus, Squamous carcinoma of the head and neck, Sexual behavior

中图分类号:

R739.6

李国俊1,2，潘新良3，雷大鹏3，陈兴明4，陈晓红5，宋西成6. 口咽部鳞状细胞癌与性行为和人乳头状瘤病毒感染[J]. 山东大学耳鼻喉眼学报, 2013, 27(1): 1-7.

Guojun Li1,2, MD, PhD, Xinliang Pan3, MD, PhD, Dapeng Lei3, MD, PhD et al. Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx[J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(1): 1-7.

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口咽部鳞状细胞癌与性行为和人乳头状瘤病毒感染

Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx

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