山东大学耳鼻喉眼学报

• 论文 • 上一篇    下一篇

颞骨骨折性面瘫手术减压时机的实验研究

罗建芬,樊兆民,王海波   

  1. 山东大学附属省立医院耳鼻咽喉-头颈外科, 济南 250021
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-02-24 发布日期:2008-02-24
  • 通讯作者: 罗建芬

Surgical opportunities on facial nerve decompression following intra-temporal facial nerve injury: an experimental study

LUO Jian-fen, FAN Zhao-min, WANG Hai-bo   

  1. Department of Otolaryngology & Head and Neck Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-02-24 Published:2008-02-24
  • Contact: LUO Jian-fen

摘要: 目的制作颞骨骨折性面瘫的动物模型,初步探讨大鼠面瘫的自然发展过程,了解不同手术减压时机面瘫的治疗效果及减压后面瘫的恢复变化过程。方法选用Wistar大鼠32只,制作颞骨骨折性面瘫动物模型。将完全面瘫的大鼠随机分成4组:对照组即不减压组,2周减压组,4周减压组,8周减压组。分别于以上不同的时间行面神经减压术,并于不同时间测定面神经刺激阈值,以观察面神经的恢复情况。结果对完全面瘫的大鼠于面瘫后1周行面神经阈值检查,对最大电流刺激(3mA)无反应。4组大鼠面神经刺激阈值的恢复速度相比,2周、4周减压组比不减压组及8周减压组快;2周减压组面神经的恢复速度比4周减压组快。结论通过血管钳钳夹大鼠的面神经骨管,可以造成颞骨骨折性面瘫的大鼠模型。面神经减压术在面神经受损后4周内进行,可缩短其面神经阈值的恢复时间;且减压时间越早,面神经的恢复速度越快。

关键词: 大鼠, 面神经, 外伤性面瘫, 手术减压, 面神经阈值

Abstract: To establish animal models of intratemporal facial nerve injury and find the natural developmental features of facial nerve injury. To explore the best time to do facial nerve decompression surgeries and to discover the laws of injured facial nerve recovery after the decompression surgeries. Methods32 200~300g female Wister rats were used, and the tympanic segments of the bone canal of the facial nerves were compressed by minimal forceps. After making the models, rats were randomly divided into 4 equal groups which were given decompression surgery at different times: within 3 weeks group, after 4 weeks group, after 8 weeks group and the control group. In the control group nothing was done. Decompression consisted of removing the crushed bone pieces and incising the epineurial sheath at the abovementioned times. The facial nerve threshold current was measured using the NIMResponse to observe the recovery of the facial nerve at intervals of 4 weeks. ResultsThe complete paralysis rats had no response to the maximal current (3mA) in the first week. No significant difference was found between the control group and the group which had decompression surgery after 8 weeks(P>0.05), but a difference between the other groups and the control group was found(P<0.05). There were significant differences among the three surgery groups(P<0.05). ConclusionsCrushing the facial nerve bone canal by minimal forceps is a reasonable method to make the animal models of intratemporal facial nerve injury. Decompression of the facial nerve performed within two months resulted in a faster recovery of the threshold current. Decompression later than two months had the same recovery speed as no decompression of the facial nerve. During the first two months, the earlier the decompression of the facial nerve was performed, the faster the facial nerve recovered.

Key words: Facial nerve, Traumatic facial paralysis, Rats, Facial nerve decompression surgery, Facial nerve threshold current

中图分类号: 

  • R683.5
[1] 陈涛,刘善平,卢永田. 中耳炎鼓室窦CT分型与手术方式初探[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 14-16.
[2] 谢邵兵,张燕妮,徐震航,张建辉,吴学文,孙虹. 外伤性面神经麻痹手术时机的系统评价[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 18-21.
[3] 王一红, 李瑞玉, 陈彩龙, 王晓燕, 林美福, 周硕. MSCT多模态三维重建观测颞骨结构及对人工耳蜗手术的指导意义[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 1-4.
[4] 王晓侠, 姚小宝, 李宏慧, 白艳霞, 张少强, 申震, 李白芽. 腮腺手术中寻找面神经技巧初探[J]. 山东大学耳鼻喉眼学报, 2015, 29(4): 48-50.
[5] 马栋, 郭承伟. 络治法对STZ诱导的糖尿病大鼠视网膜血管消化铺片中VCAM-1表达的影响[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 64-68.
[6] 慕超,王岩,李延忠. 阻塞性睡眠呼吸暂停低通气综合征合并高血压动物模型的建立[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 1-3.
[7] 苟栋明1,王海1,陈建超2. 近发际缘内头皮冠状切口径路在耳鼻咽喉头颈外科手术中应用的临床意义[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 62-64.
[8] 单良1,陈文文1,倪关森1,罗禹2. 周围性面瘫的MRI增强扫描检查和损伤节段观察及预后相关性分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 28-30.
[9] 刘悦1,4,李培华2,刘稳2,神平2,许学谷2,孙光明2,孙海清3. 大鼠面神经压榨对面神经元CNTF表达的影响[J]. 山东大学耳鼻喉眼学报, 2013, 27(1): 19-23.
[10] 刘骏1,赵宇2,邹剑2,秦学玲2. 经乳突进路面神经减压术治疗中耳胆脂瘤并发面神经损害75例[J]. 山东大学耳鼻喉眼学报, 2013, 27(1): 31-32.
[11] 全世明1,彭本刚1,高志强2. T细胞免疫缺陷小鼠创伤性面瘫模型的建立及其形态学评价[J]. 山东大学耳鼻喉眼学报, 2010, 24(6): 5-9.
[12] 方建林,高兴强,赵德安. TLR2、TLR3和TLR4 在变应性鼻炎大鼠鼻黏膜组织中的表达[J]. 山东大学耳鼻喉眼学报, 2010, 24(4): 40-44.
[13] 秦晨,王海波,李建峰,韩月臣,刘闻闻,逯素梅. 大鼠面神经损伤后神经营养因子-4的动态表达[J]. 山东大学耳鼻喉眼学报, 2010, 24(2): 17-.
[14] 张媛媛1,刘得龙2,张庆丰2,陶然1. 生后大鼠下丘GABAA受体β2和γ2亚单位的表达[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 25-28.
[15] 朱晓凤1,韩月臣1,熊文萍1,逯素梅2,李建峰2,王海波1,2,樊兆民1. 热凝脑膜中动脉对硝酸甘油致偏头痛大鼠三叉神经尾核c-fos基因表达的影响[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 61-64.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!