关键词: 慢性鼻-鼻窦炎；鼻息肉；p38 MAPK； IL-4； IFN-γ

Abstract:

To investigate the different expressions of p38 protein in chronic rhinosinusitis（CRS），nasal polyps (NP) and normal mucosa tissues, and to explore its effect on immunology cytokine. MethodTissue samples were obtained from 20 patients with chronic rhinosinusitis， 20 patients with nasal polyps and 15 patients with normal mucosa tissues. Expression of p38 MAPK was determined by the Western blot method; IL-4 and IFN-γ were determined by the ELASE method. Result① Compared with controls， expression of p38 protein was significantly increased(P<0.05),　but  was not significant between the two experimental groups  (P>0.05). ②　IL-4 was significantly increased only in ＮＰ tissues (P<0.05). ③　Compared with controls, IFN-γ was increased both in CRS and NP tissues (P<0.05), more significantly in the former. ④　There was a positive correlation between p38 protein and IL-4 in NP  and a positive correlation between p38 protein and IFN-γ in CRS tissues．Conclusion① Expressions of I-4 and  IFN-γ are different in CRS and NP. ② p38 protein may induce T cell to differentiate into Th1 or Th2 cells. ③ The inflammatory reaction of CRS and NP are not exactly the same.

Key words: Chronic rhinosinustis； Nasal polyps； p38 MAPK; IL-4; IFN-γ