脂质代谢、尿酸与突发性聋的关系

山东大学耳鼻喉眼学报

脂质代谢、尿酸与突发性聋的关系

朱文燕, 佘万东, 戴艳红, 高下, 倪容生

（南京医科大学附属鼓楼临床医学院耳鼻咽喉头颈外科，南京２１０００８）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-04-16 发布日期:2009-04-16
通讯作者: 佘万东

Relationship between lipid metabolism, uric acid and sudden
sensorineurol hearing loss

ZHU Wenyan, SHE Wandong, DAI Yanhong, GAO Xia, NI Rongsheng

(Department of Otolaryngology & Head and Neck Surgery, The Affiliated Drum Tower Clinic Medical College,
Nanjing Medical University, Nanjing 210008, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-04-16 Published:2009-04-16
Contact: SHE Wandong

摘要/Abstract

摘要： 目的探讨突发性聋与血清脂质代谢、血尿酸之间的关系。方法回顾性分析突发性聋住院患者100例的病史特点、血液学检查和影像学检查结果，检测其血清中甘油三酯、胆固醇、高密度胆固醇、低密度胆固醇、载脂蛋白ＡＩ、载脂蛋白Ｂ、血尿酸的含量。结果突发性聋组高密度胆固醇低于对照组，血尿酸值高于对照组，且差异有统计学意义（Ｐ<0.05），各年龄组之间的高密度胆固醇、尿酸值差异无统计学意义（Ｐ>0.05）。两组之间的甘油三酯、胆固醇、低密度胆固醇、载脂蛋白ＡＩ、载脂蛋白Ｂ值均差异无统计学意义。结论高密度胆固醇下降、尿酸代谢紊乱是突发性聋发生的危险因素。

关键词: 突发性聋, 脂质, 尿酸, 年龄

Abstract: To explore the relationship between changes of serum lipid metabolism, uric acid and sudden sensorineurol hearing loss(SSNHL). MethodsThe serum levels of triglyceride(TG), cholesterol(CHO), high density lipoproteincholesterol(HDLCH), low density lipoproteincholesterol(LDLCH), apolipoprotein AI(Apo AI), apolipoprotein B （Apo B）and uric acid（UA） in 100 patients with sudden sensorineurol hearing loss and 56 controls were determined. ResultsThe serum levels of high lipoproteincholesterol were significantly decreased (P<0.05) and uric acid significantly increased (P<0.05) in the sudden sensorineural hearing loss group in comparison with the control group. There were no significant differences of high　lipoproteincholesterol or uric acid in any agegroup, also there were no significant differences in levels of TG, CHO, LDLCH, AｐｏAI and AｐｏB between the sudden sensorineural hearing loss groups and the control groups（Ｐ>0.05）. ConclusionMetabolic disturbance of serum lipids and uric acid in patients with sudden sensorineurol hearing loss may be related to the etiology of sudden sensorineural hearing loss.

中图分类号:

R764.4

朱文燕, 佘万东, 戴艳红, 高下, 倪容生
. 脂质代谢、尿酸与突发性聋的关系[J]. 山东大学耳鼻喉眼学报, 2009, 23(2): 42-44 .

ZHU Wenyan, SHE Wandong, DAI Yanhong, GAO Xia, NI Rongsheng
. Relationship between lipid metabolism, uric acid and sudden
sensorineurol hearing loss[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(2): 42-44 .

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