山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (4): 101-104.doi: 10.6040/j.issn.1673-3770.0.2015.481
赵露,谢国丽,王艳玲
ZHAO Lu, XIE Guoli, WANG Yanling
摘要: 目的 探讨湿性年龄相关性黄斑变性患者经单独玻璃体腔注射雷珠单抗治疗后眼血流动力学的变化。 方法 纳入20例患者(20眼)。所有患者术前、术后1周、术后4周测量眼动脉、视网膜中央动脉、睫状动脉血流动力学参数指标,包括收缩期峰值流速(PSV),舒张末期血流速度(EDV)及阻力指数(RI),搏动指数(PI)。比较患者不同时间点眼血流动力学参数的差异性。 结果 注射眼术前,术后1、4周眼动脉、视网膜中央动脉、睫状后动脉的PSV、 EDV、RI、PI差异均无统计学意义。同样对侧眼术前,术后1、4周,眼动脉、视网膜中央动脉、睫状后动脉的PSV、 EDV、RI、PI差异均无统计学意义。 结论 单独玻璃体腔注射雷珠单抗不影响湿性AMD患者的眼血流动力学。
中图分类号:
[1] Furino C, Boscia F, Cardascia N, et al. Hemorrhagic macular infarction after intravitreal bevacizumab for central retinal vein occlusion[J]. Ophthalmic Surg Lasers Imaging, 2010, 9(1):1-2. [2] Ganssauge M, Wilhelm H, Bartz-Schmidt K U, et al. Non-arteritic anterior ischemic optic neuropathy(NA-AION)after intravitreal injection of bevacizumab(Avastin_)for treatment of angoid streaks in pseudoxanthoma elasticum[J]. GraefesArch Clin Exp Ophthalmol, 2009, 247(12):1707-1710. [3] Huang Z L, Lin K H, Lee Y C, et al. Acute vision loss after intravitreal injection of bevacizumab(avastin)associated with ocular ischemic syndrome[J]. Ophthalmologica, 2010, 224(2):86-89. [4] Mansour A M, Bynoe L A, Welch J C, et al. Retinal vascular events after intravitreal bevacizumab[J]. Acta Ophthalmol, 2010, 88(7):730-735. [5] Schmidt-Erfurth U. Clinical safety of ranibizumab in age-reIated macular degeneration[J]. Expert Opin Drug Saf, 2010, 9(1):149-165. [6] Dimitrova G, Tamaki Y, Kato S. Retrobulbar circulation in patients with age-related maculopathy[J]. Eye, 2002, 16(5):580-586. [7] Dimitrova G, Kato S. Color Doppler imaging of retinal diseases[J]. Surv Ophthalmol, 2010, 55(3):193-214. [8] Friedman E, Krupsky S, Lane A M, et al. Ocular blood flow velocity in age-related macular degeneration[J]. Ophthalmology, 1995, 102(4):640. [9] 李惠荣,李惠玲,吴秀荣,等.彩色多普勒超声对年龄相关性黄斑变性患者眼血流动力学的评价[J].山东医药, 2009, 49(41):84-85. [10] Hosseini H, Lotfi M, Esfahani M H, et al.Effect of intravitreal bevacizumab on retrobulbar blood flow in njected and uninjected fellow eyes of patients with neovascular age-related macular degeneration[J]. Retina, 2012, 32(5):967-971. [11] Toklu Y, Cakmak H B, Raza S, et al. Short-term effects of intravitreal bevacizumab(Avastin(®))on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration[J]. Acta Ophthalmol, 2011, 89(1):e41-45. [12] Yuksel K, Altinkaynak H, Kina A, et al. Can intravitreal ranibizumab alter retrobulbar circulation in eye with age- related macular degeneration?[J]. J Ocul Pharmacol Ther, 2013, 29(8):723-727. [13] Sakalar Y B, Senturk S, Yildirim M, et al. Evaluation of retrobulbar blood flow by color doppler ultrasonography after intravitreal ranibizumab injection in patients with neovascular age-related macular degeneration[J]. J Clin Ultrasound, 2013, 41(1):32-37. [14] Zhu Q, Ziemssen F, Henke-Fahle S, et al. Vitreous levels of bevacizumab and vascular endothelial growth factor-A in patients with choroidal neovascularization[J]. Ophthalmology, 2008, 115(10):1750-1755. |
[1] | 周学义,李一鸣,王美菊,张苑苑,张历浊. 25+微创玻璃体视网膜手术联合玻璃体腔注射雷珠单抗治疗增生型糖尿病视网膜病变的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 87-89. |
[2] | 王翠,颜昕,赵博军. IVR联合PDT治疗湿性年龄相关性黄斑变性的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 94-97. |
[3] | 靳琳,潘庆敏,胡磊. 玻璃体腔注射雷珠单抗治疗CSME及NCSME的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 96-98. |
[4] | 严槟,尹小芳,叶祖科,卢彦,洪剑威. 玻璃体腔注射雷珠单抗联合GLP治疗BRVO-ME的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(1): 110-113. |
[5] | 柴雪荣, 张士玺, 陶钰, 申家泉. 玻璃体腔注射雷珠单抗联合小梁切除术及全视网膜光凝治疗新生血管性青光眼的效果评价[J]. 山东大学耳鼻喉眼学报, 2015, 29(3): 72-75. |
[6] | 龚斌, 范传峰, 王玉. 抗VEGF药物(雷珠单抗)治疗不同病程湿性年龄相关性黄斑变性62例[J]. 山东大学耳鼻喉眼学报, 2014, 28(5): 58-61. |
[7] | 王宗峰,张志莉,李建东,李剑弋 . 控制性降压对鼻内镜手术视野及脑血流变化的影响[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 239-241 . |
|