鼻息肉组织和血清中MDA含量及ADA、SOD活性的测定及其意义

山东大学耳鼻喉眼学报 ›› 2010, Vol. 24 ›› Issue (6): 24-26.

鼻息肉组织和血清中MDA含量及ADA、SOD活性的测定及其意义

张燕，李桂芳，任秀敏，段乃超，杨彦忠

河北医科大学第二医院耳鼻咽喉科，石家庄 050000

收稿日期:2010-06-08 修回日期:2010-11-23 发布日期:2010-12-16
作者简介:张燕, 女，主任医师，教授，硕士生导师，主要从事鼻部疾病的临床和基础研究。 Email：Zhang yan 716713@sina.com

Determination of MDA level， ADA activity and SOD activity in the polyp and serum of patients with nasal polyps

ZHANG Yan， LI Gui-fang, REN Xiu-min, DUAN Nai-chao, YANG Yan-zhong

Department of Otolaryngology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

Received:2010-06-08 Revised:2010-11-23 Published:2010-12-16

摘要/Abstract

摘要：

目的测定鼻息肉患者鼻息肉组织和血清中丙二醛(MDA)含量、腺苷脱氨酶(ADA)和超氧化物歧化酶(SOD)的活性，并探讨其意义及它们之间的相关关系。方法用比色法分别测定24例鼻息肉患者鼻息肉组织和血清中MDA含量、ADA和SOD的活性,另20例鼻中隔偏曲患者的下鼻甲黏膜和血清作为对照组。结果 ①实验组组织和血清中MDA含量、ADA活性显著高于对照组（P<0.01）；SOD活性显著低于对照组（P<0.01）；②实验组组织和血清中MDA与ADA呈正相关（r=0.66,P<0.01），MDA和SOD呈负相关（-1

关键词: 鼻息肉;丙二醛；腺苷脱氨酶；超氧化物歧化酶

Abstract:

Objective To determine the MDA level, ADA and SOD activities and to explore their correlations in the polyp and serum of nasal polyp patients. Methods The activity of ADA, SOD and MDA level of specimens and serum were measured with the method of chromatometry, and the polyp and serum of the experiment group were obtained from 24 patients with nasal polyp. The control specimens of the inferior turbinate mucosa and serum were acquired from 20 patients with deflection of the nasal septum. Results ①The level of MDA and activity of ADA in the polyp and serum of nasal polyp patients were remarkably higher than those in the control group (P<0.01). The　activity-of-SOD-in-the polyp-and-serum-of-nasal-polyp-patients-were remarkably lower than those in the control group (P<0.01). ②There was a positive correlation between the NP group and the control group of MDA and ADA in tissues and serum（0

Key words: Nasal polyp; Malondialdehyde； Adenosine Deamicase； Superoxidedismutase

中图分类号:

R765.12

张燕，李桂芳，任秀敏，段乃超，杨彦忠. 鼻息肉组织和血清中MDA含量及ADA、SOD活性的测定及其意义[J]. 山东大学耳鼻喉眼学报, 2010, 24(6): 24-26.

ZHANG Yan，LI Gui-fang, REN Xiu-min, DUAN Nai-chao, YANG Yan-zhong. Determination of MDA level， ADA activity and SOD activity in the polyp and serum of patients with nasal polyps[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(6): 24-26.

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