下咽癌瘤内淋巴管生成及颈淋巴转移关系的研究

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (1): 24-.

下咽癌瘤内淋巴管生成及颈淋巴转移关系的研究

叶婷1，马超2，潘新良1

1. 山东大学齐鲁医院耳鼻咽喉头颈外科； 2. 山东大学卫生部耳鼻喉科学重点实验室，济南 250012

收稿日期:2010-11-16 修回日期:2010-12-22 出版日期:2011-02-16 发布日期:2011-02-16
通讯作者: 潘新良,教授，博士生导师。Email: panxinl@yahoo.com.cn
作者简介:叶婷（1985- ），女，硕士研究生，主要从事头颈肿瘤的基础与临床研究。 Email: sallyhappy.yt@163.com

Relationship between intratumoral lymphangiogenesis in hypopharyngeal neoplasms and lymphatic metastasis

YE Ting1, MA Chao2, PAN Xin-liang1

1. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University;
2. Key Laboratory of Otorhinolaryngology, Ministry of Health, Shandong University, Jinan 250012, China

Received:2010-11-16 Revised:2010-12-22 Online:2011-02-16 Published:2011-02-16

摘要/Abstract

摘要：

目的探讨D2-40在下咽癌新生淋巴管形成中的作用及其临床病理意义。方法应用淋巴管内皮特异性标志物D2-40，检测47例下咽癌患者肿瘤组织中及癌旁正常黏膜中的淋巴管密度（LVD），并与临床病理参数进行分析。结果下咽癌肿瘤组织中可观察到新生淋巴管，且肿瘤组织内高表达的LVD与淋巴结转移差异有统计学意义（P<0.05），而与患者年龄、性别、肿瘤分化程度、T分期差异无统计学意义（P>0.05）。结论下咽癌内存在新生淋巴管，且高瘤内LVD和淋巴转移相关，肿瘤可能通过瘤内新生淋巴管进行转移。

关键词: D2-40；下咽癌；淋巴管形成；淋巴管密度；淋巴转移

Abstract:

Objective To investigate the role of D2-40 in lymphangiogenesis in hypopharyngeal neoplasms and its clinical pathological significance. Methods 47 specimens of hypopharyngeal neoplasms were analyzed by immunohistochemiatry with the specific lymphatic endothelial marker D2-40. Lymphatic vessel density (LVD) was counted in the intratumoral and normal tissues, and its relationship with clinical pathological parameters was analyzed. Results Lymphangiogenesis was observed in the intratumoral tissue, and higher LVD was correlated with lymphatic metastasis(P<0.05). There was no significant association between LVD and age, gender, T stages and histological differentiation(P>0.05). Conclusions New lymphatic vessels exist in hypophyaryngeal neoplasms. There is a correlation between high LVD and lymphatic metastasis, and tumor metastasis may take place by intratumoral lymphatics.

Key words: D2-40; Hypopharyngeal neoplasm; Lymphangiogenesis; Lymphatic vessel density; Lymphatic metastasis

中图分类号:

R739.91

叶婷1，马超2，潘新良1. 下咽癌瘤内淋巴管生成及颈淋巴转移关系的研究[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 24-.

YE Ting1, MA Chao2, PAN Xin-liang1. Relationship between intratumoral lymphangiogenesis in hypopharyngeal neoplasms and lymphatic metastasis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 24-.

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