糖皮质激素对鼻息肉缺氧诱导因子-1α及血管内皮生长因子表达的影响

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (1): 53-.

糖皮质激素对鼻息肉缺氧诱导因子-1α及血管内皮生长因子表达的影响

李臻

烟台市烟台山医院耳鼻喉科, 山东烟台 264001

收稿日期:2010-06-23 修回日期:2010-12-26 出版日期:2011-02-16 发布日期:2011-02-16
作者简介:李臻，女，主要从事耳鼻喉疾病的临床研究。Email: xieruixuan20051125@yahoo.com.cn

Effects of corticosteroid on expressions of HIF-1α and VEGF in nasal polyps

LI Zhen

Department of Otorhinolaryngology, Yantaishan Hospital, Yantai 264001, Shandong, China

Received:2010-06-23 Revised:2010-12-26 Online:2011-02-16 Published:2011-02-16

摘要/Abstract

摘要：

目的探讨组织缺氧诱导因子-1α(HIF-1α）及血管内皮生长因子（VEGF）在鼻息肉组织中的表达及相关性, 探讨局部应用糖皮质激素类药物对鼻息肉的作用机制。方法采用免疫组化SP法检测鼻息肉组织在应用丙酸氟替卡松鼻喷剂治疗前、后及下鼻甲HIF-1α及VEGF的表达变化。结果鼻息肉组织中HIF-1α和VEGF的表达水平明显高于下鼻甲组织（P均＜0.01）；激素治疗后HIF-1α、VEGF表达下降(P＜0.05)。鼻息肉的发病与组织中HIF-1α、VEGF的表达呈明显正相关（r=0.627, P＜0.05）。结论局部应用糖皮质激素可降低HIF1α、VEGF的表达，有效治疗鼻息肉。　　

关键词: 糖皮质激素；鼻息肉；缺氧诱导因子1α；血管内皮生长因子

Abstract:

Objective To study expression and relationship of hypoxia-inducible factor-1α （HIF-1α） and vessel endothelium growth factor（VEGF ）in nasal polyps, and to investigate the mechanism of action of corticosteroid on these cell factors. Methods Expressions of HIF-1α and VEGF in nasal polyps before and after treatment with corticosteroid were detected by SP immunohistochemical methods, and their relationship was calculated by linear correlation analysis. Results Expressions of HIF1α and VEGF in nasal polyps were higher than those in inferior turbinate tissues. Expressions of HIF-1α and VEGF were significantly reduced in nasal polyps after treatment with corticosteroid. There was a positive correlation between expression of HIF-1α and that of VEGF. Conclusion Corticosteroid is effective in nasal polyps by restraining expressions of HIF-1α and VEGF.

Key words: Corticosteroid; Nasal polyps; Hypoxiainducible factor; Vessel endothelium growth factor

中图分类号:

R765.25

李臻. 糖皮质激素对鼻息肉缺氧诱导因子-1α及血管内皮生长因子表达的影响[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 53-.

LI Zhen. Effects of corticosteroid on expressions of HIF-1α and VEGF in nasal polyps[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 53-.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	王丽娟1，左敏2，高国凤1，曾少明1，张伟1，刘明1. 神经生长因子及其受体在鼻息肉中的表达及意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(6): 49-.
[2]	张敏，夏立军. IL-17对鼻息肉中巨噬细胞炎性蛋白-3α的影响[J]. 山东大学耳鼻喉眼学报, 2011, 25(2): 37-40.
[3]	庄夏衍1综述，王挥戈2审校. 鼻息肉组织中各种浸润细胞的意义及相互间的作用[J]. 山东大学耳鼻喉眼学报, 2010, 24(2): 47-54.