喉鳞状细胞癌组织中骨桥蛋白和p53的表达及其临床意义

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (2): 19-22.

喉鳞状细胞癌组织中骨桥蛋白和p53的表达及其临床意义

陈剑秋1,2，朱敏辉1，邱晓霞1，夏思文1，叶犇2，陈世彩1，郑宏良1

1.第二军医大学附属长海医院耳鼻咽喉-头颈外科，上海 200433；
2. 济南军区总医院耳鼻咽喉-头颈外科，济南 250031

收稿日期:2011-02-11 修回日期:2011-03-04 出版日期:2011-04-16 发布日期:2011-04-16
通讯作者: 郑宏良（1962- ），男，博士，主任医师，教授，博士生导师，主要从事头颈肿瘤及嗓音外科学的临床与研究工作。 Email：zheng-hl2004@163.com
作者简介:陈剑秋（1970- ），女，博士研究生，副主任医师，主要从事头颈肿瘤基础及临床方面的研究。 Email：jianqiuc2008@163.com

Expressions and clinical significances of osteopontin and p53 in laryngeal squamous cell carcinoma tissues

CHEN Jian-qiu1,2, ZHU Min-hui1, QIU Xiao-xia1, XIA Si-wen1,YE Ben2, CHEN Shi-cai1, ZHENG Hong-liang1

1. Department of Otolaryngology and Head & Neck Surgery, Changhai Hospital of the Second Military
Medical University, Shanghai 200433, China；
2. Department of Otolaryngology and Head & Neck Surgery, Jinan Military General Medical Hospital, Jinan 250031, China

Received:2011-02-11 Revised:2011-03-04 Online:2011-04-16 Published:2011-04-16

摘要/Abstract

摘要：

目的研究人喉鳞状细胞癌（LSCC）及其癌旁相对正常组织中骨桥蛋白 (OPN)和p53表达水平，并探讨两者的相互关系及其临床病理学意义。方法采用免疫组织化学SP法,对44例LSCC及癌旁组织手术切除标本常规制作石蜡包埋切片，检测OPN和p53的表达，结合喉癌患者的临床病理学特征进行分析。结果 ①44例喉癌组织中OPN和p53表达阳性率分别为75.0%（33例）和65.9%（29例）,癌旁相对正常组织中分别为13.6%（6例）和2.3%（1例）；②OPN的表达与颈部淋巴结转移、临床分期、病理组织学分级有关，与性别、年龄、原发部位无相关性；③OPN和p53的表达呈显著正相关（r＝0. 360，P＝0.016）。结论 OPN在喉癌组织中的表达高于癌旁相对正常组织，可能参与了喉癌的发生、发展和转移，有可能成为判断预后的重要生物学标记物。

关键词: 喉肿瘤；癌，鳞状细胞；骨桥蛋白；p53

Abstract:

Objective To study OPN and p53 expressions and detect their correlation and clinicopathological value in laryngeal squamous cell carcinoma (LSCC) and adjacent tissues. Methods The SP immunohistochemical method was used to study the OPN and p53 expressions in routinely embedded sections of surgical specimens of 44 laryngeal squamous cell carcinomas and adjacent tissues，and clinicopathological features were analyzed. Results ①The positive rates of OPN and p53 protein were 75.0 %（33 cases）and 65.9%（29 cases）in LSCC, and 13.6%（6 cases）and 2.3%（1 case）in adjacent tissue respectively; ②The OPN expression level was significantly correlated with tumor stage, grade and the presence of lymph nodes, but was not correlated with age, gender and primary tumor site; ③Expression of OPN was positively correlated with that of p53(r＝0. 360，P＝0.016). Conclusions OPN expression is higher in LSCC than in adjacent tissue, and may participate in the development and metastasis of LSCC. OPN might be an important biological marker in LSCC prognosis.

Key words: Laryngeal neoplasms； Carcinoma, squamous cell； Osteopontin； p53

中图分类号:

R739. 65

陈剑秋1,2，朱敏辉1，邱晓霞1，夏思文1，叶犇2，陈世彩1，郑宏良1. 喉鳞状细胞癌组织中骨桥蛋白和p53的表达及其临床意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(2): 19-22.

CHEN Jian-qiu1,2, ZHU Min-hui1, QIU Xiao-xia1, XIA Si-wen1,YE Ben2, CHEN Shi-cai1, ZHENG Hong-liang1. Expressions and clinical significances of osteopontin and p53 in laryngeal squamous cell carcinoma tissues[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 19-22.

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