山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (4): 44-47.

• 论文 • 上一篇    下一篇

经鼻内镜鼻窦术后自控静脉镇痛对血浆IL-6、IL-10的影响

伍红良1,高延永1,庾俊雄2,  陶赞英3,刘强和1,何晓松1,耿宛平1   

  1. 桂林医学院附属医院 1.耳鼻咽喉头颈外科;2.麻醉科;3.中心实验室,广西 桂林541001
  • 收稿日期:2011-02-08 修回日期:2011-04-28 出版日期:2011-08-16 发布日期:2011-08-16
  • 通讯作者: 耿宛平,教授,主要从事头颈肿瘤及鼻部疾病的临床与基础研究。
  • 作者简介:伍红良,男,主治医师,主要从事鼻部疾病的临床与基础研究。
  • 基金资助:

    广西卫生厅科研项目(Z2008253 );广西医疗卫生重点科研课题重(200882)。

Effect of patient-controlled intravenous analgesia for endoscopic sinus surgery on plasma IL-6 and IL-10

WU Hongliang1, GAO Yanyong1, YU Junxiong2, TAO Zanying3, LIU Qianghe1,  HE Xiaosong1, GENG Wanping1   

  1. Department of Otolaryngology & Head and Neck Surgery, Affiliated Hospital of Guilin  Medical University, Guilin 541001, Guangxi,  China
  • Received:2011-02-08 Revised:2011-04-28 Online:2011-08-16 Published:2011-08-16

摘要:

目的      探讨经鼻内镜鼻窦手术后自控静脉镇痛的效果及对细胞因子IL-6、IL-10的影响。方法      随机选择ASAⅠ~Ⅱ级择期行功能性鼻内镜鼻窦手术的患者40例,随机分为Ⅰ组: 0.002mg/kg舒芬太尼PCA镇痛组; Ⅱ组:患者视觉模拟疼痛评分(visual analog analgesia, VAS)>4或者患者要求镇痛时给与尼美舒利颗粒0.1g口服。分别记录并比较术后各时间点VAS评分及不良反应发生率。分别于麻醉前,术后8,24,48h抽取外周静脉血检测血清IL-6、IL-10水平。结果       Ⅰ组镇痛效果满意。48h内各时间点,VAS评分Ⅱ组大于Ⅰ组(P<0.05), 血压、血氧、心率、呼吸两组比较差异无统计学意义(P>0.05),两组术后IL-6、IL-10均升高(P<0.05),Ⅱ组术后IL-6升幅较Ⅰ组显著(P <0.05),Ⅰ组IL-10升幅较Ⅱ组显著(P<0.05)。结论       自控静脉镇痛在经鼻内镜鼻窦手术后取得良好镇痛效果,并且有效地维持细胞因子的平衡,缓解术后的免疫损伤。

关键词: 鼻内镜手术;疼痛;自控静脉镇痛;IL-6;IL-10

Abstract:

Objective      To evaluate patient-controlled intravenous analgesia for endoscopic sinus surgery and its effect on cytokines IL-6 and  IL-10. Methods     40 patients(ASAⅠⅡ) undergoing elective endoscopic sinus surgery were randomly divided into two groups: GroupⅠ (n=20, Sufentanil 0.002mg/kg normal saline diluted to 100mL )and Group Ⅱ (n=20, Nimesulide 0.1g,P.O,when VAS>4 or analgesic requirements in patients). Differences of VAS, blood pressure, blood oxygen, heart rate, breathing and adverse reactions were compared between the two groups at each time point. Blood serum concentrations of IL-6 and IL-10 were measured before and at postoperative 8h, 24h and 48h. Results      Satisfaction with the analgesic effect of the groupⅠ.VAS score: group Ⅱ was significant higher than  group Ⅰ(P<0.05). No significant differences between the two groups were found in blood pressure, blood oxygen, heart rate, breathing (P>0.05).There was a significant increase in the levels of IL-6 and IL10 in both groups comparing with those before anesthesia(P<0.05), IL-6 in group Ⅱ increased  significantly compared with that in the  group Ⅰ at post-operative time points(P<0.05), IL-10  in the  group Ⅰ increased significantly compared with that in the group Ⅱ at post-operative time points (P<0.05). Conclusion      Intravenous patient-controlled analgesia in endoscopic sinus surgery has a good analgesic effect,which can provide efficient effect in maintaining the balance of pro/antiinflammatory cytokines, and ease postoperative immune injury.

Key words:  Endoscopic sinus surgery; Pain; Patient-controlled intravenous analgesia; IL-6; IL-10

中图分类号: 

  • R739.65
[1] 贾传亮,王丽综述,陈秀梅,宋西成审校. T1b声门型喉癌的治疗进展[J]. 山东大学耳鼻喉眼学报, 2012, 26(6): 83-83.
[2] 卢国伟,王琳,孙彦,李薇,华辉,葛瑞峰. 山东东部57例喉癌人乳头状瘤病毒DNA及其亚型的检测[J]. 山东大学耳鼻喉眼学报, 2012, 26(6): 16-19.
[3] 孙睿杰,许风雷,刘大昱,雷大鹏,潘新良. 显微支撑喉镜下CO2激光手术或联合干扰素治疗复发性小儿喉乳头状瘤疗效对比[J]. 山东大学耳鼻喉眼学报, 2012, 26(6): 23-25.
[4] 陈勇,谢秀芳,刘昉,蒋刈,李瑞玉. IFN-γ转染骨髓间充质干细胞治疗喉乳头状瘤的实验研究[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 24-27.
[5] 张书嘉1, 李培华2, 贾文波1, 徐恒光1, 鲍凤香1,李利1. 程序性细胞死亡因子5在喉鳞状细胞癌组织中的表达及临床意义[J]. 山东大学耳鼻喉眼学报, 2012, 26(2): 23-26.
[6] 吴桂卿1,田军2,孙静1,陈琪1. Tiam1和MTA1在喉鳞癌组织中的表达及意义[J]. 山东大学耳鼻喉眼学报, 2012, 26(1): 41-43.
[7] 李大伟,董频,高尚. 喉鳞癌中P糖蛋白表达与细胞增殖、凋亡及预后的关系[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 8-12.
[8] 温晗光,陈缪安,林忠豪,蔡志良. 喉神经内分泌癌1例[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 73-74.
[9] 徐宏鸣,董频,孙臻峰,王国良,王菲. 喉腔手术动物模型的初步研究[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 15-.
[10] 伊海金1, 张宝泉2, 王春红1, 郭泓1, 倪富强1. 喉癌治疗后复发的临床因素分析及治疗[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 18-21.
[11] 李志章1,李钦2,耿玉艳3,邵阳1. TGF-β1/Smad4信号通路在喉鳞癌中的作用及意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(2): 16-.
[12] 姜绍红,宋西成,张庆泉,朱宇宏,孙岩,张华,王强. 导航鼻内镜下治疗鼻窦囊肿[J]. 山东大学耳鼻喉眼学报, 2011, 25(2): 60-62.
[13] 孙岩,宋西成,张庆泉,张华,柳忠禄,王强,姜绍红,刘斐斐. 导航鼻内镜下上颌窦良性骨性病变的治疗体会[J]. 山东大学耳鼻喉眼学报, 2011, 25(2): 63-.
[14] 曾志梅1,梁永辉2,杨嶷芳2, 窦晓清2, 罗碧强2,张丽卫2,陈贤明2. 巨噬细胞移动抑制因子在下咽癌中的表达[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 17-19.
[15] 高尚,董频,李大伟,沈斌. 血小板衍生生长因子-BB对喉癌Hep2细胞增殖侵袭的影响及其可能分子机制[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 20-23.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!