神经生长因子及其受体在鼻息肉中的表达及意义

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (6): 49-.

神经生长因子及其受体在鼻息肉中的表达及意义

王丽娟1，左敏2，高国凤1，曾少明1，张伟1，刘明1

深圳市人民医院暨南大学第二临床学院 1．耳鼻咽喉科， 2．病理科，广东深圳 518020

收稿日期:2011-10-06 修回日期:2011-11-09 出版日期:2011-12-16 发布日期:2011-12-16
通讯作者: 刘明，男,博士,主任医师,教授，硕士生导师,主要从事鼻科学的临床和基础研究。 Email：mingliu19561225@yahoo.com.cn
作者简介:王丽娟，硕士，副主任医师，主要从事鼻科学的临床和基础研究。
基金资助:
广东省医学科研基金(A2008598)

Expression of nerve growth factor and its receptors in human nasal polyps

WANG Li-juan1， ZUO Min2, GAO Guo-feng1， ZENG Shao-ming1， ZHANG Wei1， LIU Ming1

1. Department of Otorhinolaryngology; 2. Department of Pathology, Shenzhen People′s Hospital，
Second Clinical Medical College of Jinan University， Shenzhen 518020， Guangdong, China

Received:2011-10-06 Revised:2011-11-09 Online:2011-12-16 Published:2011-12-16

摘要/Abstract

摘要：

目的探讨神经生长因子(nerve growth factor，NGF)及其受体在鼻息肉组织中的表达。方法采用免疫组化ABC法，检测20例鼻息肉组织(鼻息肉组)及6例正常下鼻甲黏膜(对照组)中NGF及其受体的表达。结果对照组：正常下鼻甲黏膜中NGF及其受体的表达呈阴性；鼻息肉组：其黏膜上皮层和黏膜下层中NGF染色阳性率分别是90%(18/20)和95%(19/20)；在鼻息肉组织同样位置发现了NGF的高亲和性受体TrKA(Tyrosine kinase A)高表达，在纤毛上皮细胞和腺上皮细胞中发现了NGF的低亲和性受体P75高表达。结论 NGF在鼻息肉组织中具有高表达特征，表明NGF在鼻息肉发生发展机制中发挥着重要作用。

关键词: 神经生长因子；鼻息肉；下鼻甲

Abstract:

Objective To confirm expression of nerve growth factor (NGF) and its receptors in human nasal polyps. Methods Expressions of nerve growth factor and its receptors were detected in 20 specimens of nasal polyps and 6 samples of normal inferior turbinates by the ABC immunohistochemical technique.Results Normal inferior turbinates had no expression of nerve growth factor and its receptors. Expressions of nerve growth factor, which were TrKA in the mucosa and submucosa of nasal polyps were 90%(18/20) and 95%(19/20), and expression of TrKA in the same tissue were also high, but were P75 in cilium cells and in the glands. Conclusion Nerve growth factor is mainly distributed in the human nasal polyps. High expression of nerve growth factor indicates it may be involved in the development of nasal polyps．

Key words: Nerve growth factor； Nasal polyps； Inferior turbinate

中图分类号:

R765.25

王丽娟1，左敏2，高国凤1，曾少明1，张伟1，刘明1. 神经生长因子及其受体在鼻息肉中的表达及意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(6): 49-.

WANG Li-juan1， ZUO Min2, GAO Guo-feng1， ZENG Shao-ming1， ZHANG Wei1， LIU Ming1. Expression of nerve growth factor and its receptors in human nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(6): 49-.

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