盐酸氨溴索治疗分泌性中耳炎疗效的Meta分析

山东大学耳鼻喉眼学报 ›› 2012, Vol. 26 ›› Issue (3): 10-12.

盐酸氨溴索治疗分泌性中耳炎疗效的Meta分析

侯森1，杨海珍2

阳谷县人民医院 1.耳鼻喉科； 2.病理科，山东阳谷 252300

收稿日期:2012-02-26 出版日期:2012-06-16 发布日期:2012-06-16
作者简介:侯森。 Email:sdhousen@163.com

Effect of ambroxol hydrochloride on secretory otitis media： A meta-analysis

HOU Sen1， YANG Hai-zhen2

1. Department of Otorhinolaryngology, 2. Department of Pathology,Yanggu People′s Hospital, Yanggu 252300, Shandong, China

Received:2012-02-26 Online:2012-06-16 Published:2012-06-16

摘要/Abstract

摘要：

目的系统评价盐酸氨溴索治疗分泌性中耳炎的效果。方法通过检索Pubmed、CNKI和万方数据库，以 “分泌性中耳炎”和 “盐酸氨溴索”为主题词检索盐酸氨溴索治疗分泌性中耳炎的随机对照试验研究(RCT),并辅以手工检索进行文献追索。以常规治疗为对照组，盐酸氨溴索治疗分泌性中耳炎为治疗组，提取纳入研究文献原始数据，并进行Meta分析。结果 14篇文献被纳入本次研究，共1412例分泌性中耳炎患者，其中治疗组743例，对照组669例。Meta分析结果显示，盐酸氨溴索治疗分泌性中耳炎效果优于常规治疗(P<0.05)，总有效率合并OR及其95%CI为2.74(2.10,3.57)。结论盐酸氨溴索能提高治疗分泌性中耳炎疗效，仍需对药物的不良反应通过大样本、多中心研究。

关键词: 盐酸氨溴索;分泌性中耳炎；Meta分析

Abstract:

Objective To evaluate the effects of ambroxol hydrochloride on secretory otitis media. Methods Randomized, controlled trials(RCT) of ambroxol hydrochloride in the treatment of secretory otitis media, published in Pubmed, CNKI and Wanfang databases, were collected. The methodological quality of the trials and the valid data were evaluated by Meta-analysis. Results 14 RCT and 1412 patients were included in this study. Meta analysis showed that the treatment group was better than the control. The general OR and 95%CI for the overall efficacy was 2.74(2.103.57). Conclusion Ambroxol hydrochloride can improve the treatment of secretory otitis media，however, there were still some side effects found in the large sample, multi-center study.

Key words: Ambroxol Hydrochloride; Secretory otitis media; Meta-analysis

中图分类号:

R764.1

侯森1，杨海珍2. 盐酸氨溴索治疗分泌性中耳炎疗效的Meta分析[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 10-12.

HOU Sen1， YANG Hai-zhen2. Effect of ambroxol hydrochloride on secretory otitis media： A meta-analysis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 10-12.

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