关键词: 中耳炎，分泌性；细胞因子；免疫机制

Abstract:

There were a lot of researchs performed on the immunologic mechanism related to otitis media with effusion(OME) at home and abroad in the recent years, especially the type I allergy, cytokines related to Th1/Th2 , the interactions among these cytokines  and tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ), nuclear transcription factors kappa B (NF-kB), oxygen radicals, hypoxia inducible factor-1α(HIF-1α), transforming growth factor-β(TGF-β), or intercellular adhesion molecule (ICAM). The progress was reviewed and some new ideas is to be proposed in this paper. 

Key words: Otitis media with effusion; Cytokine; Immunologic mechanism