山东大学耳鼻喉眼学报 ›› 2012, Vol. 26 ›› Issue (5): 22-24.

• 论著 • 上一篇    下一篇

Caveolin-1在下咽鳞癌中的表达及其临床意义

叶萍,孙睿杰,金童,钱晔,魏东敏,潘新良   

  1. 山东大学齐鲁医院耳鼻咽喉头颈外科; 卫生部耳鼻咽喉科学重点实验室, 济南  250012
  • 收稿日期:2012-03-31 发布日期:2012-10-16
  • 通讯作者: 潘新良,博士生导师。E-mail:panxinl@yahoo.com.cn
  • 作者简介:叶萍。E-mail:yeping0531@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(30772411)

Expression and significance of Caveolin-1 in hypopharyngeal carcinoma

YE Ping, SUN Rui-jie, JIN Tong, QIAN Ye, WEI Dong-min, PAN Xin-liang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University/Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, China
  • Received:2012-03-31 Published:2012-10-16

摘要:

目的    研究Caveolin-1在下咽鳞癌组织中的表达情况,探讨其在下咽鳞癌发生发展中的作用机制。方法    采用免疫组化法检测Caveolin-1在69例下咽鳞癌及10例癌旁正常组织中的表达,统计分析两者之间的相关性。结果    Caveolin-1在下咽癌组织中的阳性率为34.78%,在对照组中Caveolin-1存在个别表达或无阳性表达,两者表达差异有统计学意义(P<0.05);Caveolin-1的表达程度与病理类型、转移相关,而与下咽鳞癌患者性别、临床分期和原发部位之间差异无统计学意义(P>0.05)。结论    下咽鳞癌中Caveolin-1的表达明显增高并与肿瘤的转移行为有关,有可能作为下咽鳞癌预后不良的病理标志之一。

关键词: 下咽肿瘤;肿瘤,鳞状细胞;Caveolin-1

Abstract:

Objective    To evaluate the expression of caveolin-1 in hypopharyngeal squamous cell carcinoma (HSCC) and investigate its association with pathological features and clinical outcome. Methods    Caveolin-1 expression was determined by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 69 paraffin embedded primary HSCC and 10 normal hypopharyngeal mucosa specimens. Associations between caveolin-1 expression and pathological features and clinical outcomes were analyzed with a chi-square test. Results    The caveolin-1 expression in HSCC was much higher than in the normal mucosa. The positive rate of caveolin-1 was 0% in the normal mucosa but 34.78% in the primary tumors. Increased caveolin-1 expression had been reported to be associated with various pathological parameters, including higher Gleason score and lymph node metastasis. Although no significant association between caveolin-1 expression and gender or primary position was observed, caveolin1 was  distinctively increased in cases with lymph node metastases (P<0.05). Conclusion    Over-expression of Caveolin-1 could be a common finding in the aggressive types of HSCC. Caveolin-1 might play an important role in invasion and metastatic progression of HSCC.

Key words: Hypopharyngeal carcinoma; Squamous cell carcinoma; Caveolin-1

中图分类号: 

  • R739.6
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