山东大学耳鼻喉眼学报 ›› 2014, Vol. 28 ›› Issue (5): 76-78.doi: 10.6040/j.issn.1673-3770.0.2014.142

• 论著 • 上一篇    下一篇

角膜基质层注射治疗真菌性角膜炎

帅少帅, 何夏怡, 宁红珠, 罗友琼, 梁斯敏   

  1. 肇庆医学高等专科学校附属医院眼科中心, 广东 肇庆 526020
  • 收稿日期:2014-04-30 发布日期:2014-10-16
  • 作者简介:帅少帅。E-mail: 1484274363@qq.com
  • 基金资助:
    广东肇庆市科技创新计划项目(No.2012E362)

Clinical observation of corneal stronmal layer injection in the treatment of fungal keratitis

SHUAI Shao-shuai, HE Xia-yi, NING Hong- zhu, LUO You-qiong, LIANG Si-min   

  1. Eye Centre, Affiliated Hospital of Zhaoqing Medical College, Zhaoqing 526020, Guangdong, China
  • Received:2014-04-30 Published:2014-10-16

PDF (PC)

801

摘要： 目的 观察角膜基质层注射氟康唑注射液治疗真菌性角膜炎的临床效果。方法 将诊断为真菌性角膜炎的70眼随机分为对照组和实验组，每组35眼。对照组：碘酊烧灼角膜溃疡后用重组牛碱性成纤维细胞生长因子眼胶及氟康唑眼膏包眼。实验组：角膜基质层注射氟康唑注射液于角膜溃疡后用重组牛碱性成纤维细胞生长因子眼胶及氟康唑眼膏包眼。观察和对比碘酊烧灼和角膜基质层注射氟康唑注射液治疗真菌性角膜炎的临床可行性。结果 实验组所有溃疡愈合，病程缩短，效果优于对照组(P(<0.05)。两组治疗前后视力平均值差异有统计学意义(P<0.05)。结论 角膜基质层注射氟康唑注射液治疗真菌性角膜炎可以明显提高治愈率，是一种高效、安全的治疗方法。

关键词: 优碘, 角膜基质层注射, 氟康唑注射液, 真菌性角膜炎

Abstract: Objective To observe clinical effect of the stromal layer of fluconazole injection of fungal keratitis. Methods 70 eyes diagnosed as fungal keratitis were randomly divided to two groups with 35 eyes in each. The treatment group was firstly treated helcoma with stomal layer of fluconazole injection, then treated with fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The control group was firstly treated helcoma with iodine cautery and then used fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The clinical feasibility of iodine cautery and the stromal layer of fluconazole injection in the treatment of fungal keratitis were observed and compared. Results Thirty-five eyes in the treatment group used the stromal layer of fluconazole injection, all helcoma healed up. The course was shorten and the effect was better than the control group(P<0.05).The average visual acuity of two groups before and after treatment was statistical different(P<0.05). Conclusion Corneal stromal layer injection in the treatment of fungal keratitis can enhance the curative rate obviously. It is an effective and safe therapeutic method.

Key words: Povidone iodine, Corneal stronmal layer injection, Fluconazole injection, Fungal keratitis

中图分类号: 

  • R772.21
[1] 赵堪兴. 眼科学[M].8版.北京：人民卫生出版社,2008:121-127.
[2] 伍尚贤. 优碘联合大扶康治疗真菌性角膜溃疡的疗效分析[J]. 国际医药卫生导报,2004,10 (22)：73-74. WU Shangxian. Effect of Betadine in combination with Diflucan in the treatment of fungal corneal ulcer[J]. Inter Med Health Guid News, 2004, 10 (22)：73-74.
[3] 张爱知. 实用药物手册[M].5版.上海：上海科技出版社,2005：394-395.
[4] 罗瑛,曾祥云,王辉.0.5%氟康唑联合碘酊治疗真菌性角膜炎30例[J].赣南医学院学报,2006,26(4):493-494. LUO Ying, ZENG Xiangyun, WANG Hui. Fluconazole and iodine tincture 0.5% for 30 cases of fungal keratitis[J]. J Gannan Med University, 2006, 26(4):493-494.
[5] 张润珍. 伊曲康唑治疗糖尿病患者真菌性角膜炎的临床疗效[J].临床眼科杂志,2013,21(5):441-442. ZHANG Runzhen. The curative effect of itraconazole in treatment for keratomycosis in diabetic patients[J]. J Clin Ophthalmol, 2013, 21(5):441-442.
[6] 席祖莲,张汉武,郭德芳,等.氟康唑联合聚维酮碘治疗真菌性结膜炎[J]. 中国眼耳鼻喉科杂志, 2010,10(6):378. XI Zulian, ZHANG Hanwu, GUO Defang, et al. Fluconazole and povidone iodine in the treatment of fungal conjunctivitis[J]. Chin J Ophthalmol Otorhinolaryngol, 2010, 10(6):378.
[1] 韩萍. 更昔洛韦滴眼液联合贝复舒治疗单疱病毒性角膜炎疗效分析[J]. 山东大学耳鼻喉眼学报, 2014, 28(3): 73-74.
[2] 崔长霞1，朱伟2，张春晓3，李志伟3. 核黄素／UVA诱导的角膜交联术治疗真菌性角膜溃疡[J]. 山东大学耳鼻喉眼学报, 2013, 27(5): 68-70.
[3] 郭慧，吴欣怡. 病毒性角膜内皮炎1例[J]. 山东大学耳鼻喉眼学报, 2012, 26(2): 2-2.
[4] 刘志谦. 结膜瓣遮盖术治疗难治性角膜溃疡27例[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 78-79.
[5] 张颖，吴欣怡. 社区人群感染性角膜炎的认知及健康教育调查[J]. 山东大学耳鼻喉眼学报, 2010, 24(4): 52-54.
[6] 凌受良 席玲 席兴华. 玉屏风散联合抗病毒治疗复发性单纯疱疹病毒性角膜炎疗效观察[J]. 山东大学耳鼻喉眼学报, 2008, 22(6): 551-552.
[7] 靳雷 崔建萍. 共焦显微镜在角膜溃疡病原学诊断中的临床应用[J]. 山东大学耳鼻喉眼学报, 2008, 22(6): 549-550.
[8] 陈凯1，张玉光2，韩旭光2，徐湘辉2，丁刚2. 角膜内皮炎药物治疗后内皮细胞的观察[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 82-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发