室内空气污染物及饮食结构对变应性疾病的影响

doi:10.6040/j.issn.1673-3770.0.2016.071

摘要/Abstract

摘要： 近年来,变应性疾病的发病率逐年上升,常见的变应性疾病包括变应性鼻炎、变应性哮喘和湿疹,其临床症状严重影响患者的生活质量,甚至危及患者生命(如重症哮喘)。多项研究已证实,空气污染物及饮食结构与变应性疾病密切相关,其潜在的发病机制成为研究热点。综述几种主要室内环境污染物以及饮食结构对变应性疾病的影响,并对其可能的发病机制进行阐述。

关键词: 空气污染, 室内环境, 饮食结构, 发病机制, 变应性疾病

Abstract: Recently, the prevalence of allergic disease increased rapidly. Common allergic diseases mainly include allergic rhinitis,allergic asthma and eczema. Clinical symptoms seriously affect the patients’ quality of life. Currently, some studies have defined the relation between indoor air pollutants and allergic diseases as well as that between diet and allergic diseases. The potential pathogenesis has become hotspot in recent years. This paper reviews the impact of several main indoor air pollutants and diet to allergic diseases. Potential mechanism also be elaborated in this review.

Key words: Diet, Air pollutants, Indoor, Allergy, Etiology

中图分类号:

R765.2

刘哲综述, 滕博,文连姬审校. 室内空气污染物及饮食结构对变应性疾病的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 96-102.

LIU Zhe, TENG Bo, WEN Lianji. The impact of indoor air pollutants and diet to allergic diseases.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 96-102.

参考文献

[1] 张清照, 朱鲁平, 程雷. 益生菌对变应性疾病的防治作用[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(7):604-608.
[2] Global Initiative for Asthma. Global strategy for asthma management and prevention[R]. GINA, 2012
[3] World Allergy Organization White Book on Allergy 2011-2012[R].WAO, 2011
[4] World Health Organization. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach[R]. Bousquet J, Khaltaev N. 2007.
[5] Pawankar R, Canonica G W, Holgate S T, et al. WAO White book on allergy[R]. Milwaukee(WI): World Allergy Organization, 2011.
[6] Ellwood P, Asher M I, García-Marcos L, et al. ISAAC Phase III Study Group. Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood(ISAAC)phase three[J]. Thorax,2013,68(4):351-360.
[7] Wood L G, Garg M L, Gibson P G. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma[J]. Allergy Clin Immunol, 2011, 127(5):1133-1140.
[8] Cepeda A M, Del Giacco S R, Villalba S, et al. A traditional diet is associated with a reduced risk of eczema and wheeze in colombian children[J]. Nutrients, 2015,7(7):5098-5110.
[9] Chatzi L, Kogevinas M. Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children[J]. Public Health Nutr, 2009, 12(9A):1629-1634.
[10] Chatzi L, Apostolaki G, Bibakis I, et al. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete[J]. Thorax, 2007, 62(8):677-683.
[11] Wood L G, Garg M L, Smart J M, et al. Manipulating antioxidant intake in asthma: a randomized controlled trial[J]. Am J Clin Nutr, 2012, 96(3):534-543.
[12] Wallace L A, Mitchell H, OConnor G T, et al. Particle concentrations in inner-city homes of children with asthma: the effect of smoking, cooking, and outdoor pollution[J]. Environ Health Perspect, 2003, 111(9):1265-1272.
[13] World Health Organization. Second-hand smoke: assessing the burden of disease at national and local levels. Geneva: WHO Environmental Burden of Disease Series, No. 18[R]. Geneva: World Health Organization, 2008.
[14] Feleszko W, Ruszczyński M, Jaworska J, et al. Environmental tobacco smoke exposure and risk of allergic sensitisation in children: a systematic review and meta-analysis[J]. Arch Dis Child, 2014, 99(11):985-992.
[15] Thacher J D, Gruzieva O, Pershagen G, et al. Parental smoking and development of allergic sensitization from birth to adolescence[J]. Allergy, 2015,doi: 10.1111/all.12792.
[16] Shargorodsky J, Garcia-Esquinas E, Galán I, et al. Allergic Sensitization, Rhinitis and Tobacco Smoke Exposure in US Adults[J]. PLoS One, 2015, 10(7):e0131957
[17] Andrews A L, Shirley N, Ojukwu E, et al. Is secondhand smoke exposure associated with increased exacerbation severity among children hospitalized forasthma?[J]. Hosp Pediatr, 2015, 5(5):249-255.
[18] Abramson M J, Schindler C, Schikowski T, et al. Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity[J]. Allergol Int, 2015, doi: 10.1016/j.alit.2015.11.004.
[19] Shargorodsky J, Garcia-Esquinas E, Navas-Acien A, et al. Allergic sensitization, rhinitis, and tobacco smoke exposure in U.S. children and adolescents[J]. Int Forum Allergy Rhinol, 2015, 5(6):471-476.
[20] U.S. Environmental Protection Agency. The Inside Story: A Guide to Air Quality[R]. Office of Radiation and Indoor Air(6609J): Washington, DC, USA, 2009.
[21] Herberth G, Gubelt R, Röder S, et al. LISAplus study group. Increase of inflammatory markers after indoor renovation activities: the LISA birth cohort study[J]. Pediatr Allergy Immunol, 2009, 20(6):563-570.
[22] Choi H, Schmidbauer N, Sundell J, et al. Common household chemicals and the allergy risks in pre-school age children[J]. PLoS One, 2010, 5(10):e13423.
[23] Matsunaga I, Miyake Y, Yoshida T, et al. Osaka Maternal and Child Health Study Group. Ambient formaldehyde levels and allergic disorders among Japanese pregnant women: baseline data from the Osaka maternal and child health study[J]. Ann Epidemiol,2008,18(1):78-84.
[24] Billionnet C, Gay E, Kirchner S, et al. Quantitative assessments of indoor air pollution and respiratory health in a population-based sample of French dwellings[J]. Environ Res, 2011, 111(3):425-434.
[25] Venn A J, Cooper M, Antoniak M, et al. Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children[J]. Thorax, 2003, 58(11):955-960.
[26] Gee I L, Watson A F R, Tavernier G, et al. Indoor air quality, environmental tobacco smoke and asthma: a case control study of asthma in a community population[J]. Indoor Built Environ, 2005, 14(2):215-219.
[27] Tavernier G, Fletcher G, Gee I, et al. IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children[J]. Allergy Clin Immunol, 2006, 117(3):656-662.
[28] Singh A B, Kumar P. Aeroallergens in clinical practice of allergy in India. An overview[J]. Ann Agric Environ Med, 2003, 10(2):131-136.
[29] Fereidouni M, Hossini R F, Azad F J, et al. Skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Iran[J]. Allergol Immunopathol(Madr), 2009, 37(2):73-79.
[30] Salo P M, Arbes S J Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey(NHANES)2005-2006[J]. Allergy Clin Immunol, 2014, 134(2):350-359.
[31] Dottorini M L, Bruni B, Peccini F, et al. Skin prick-test reactivity to aeroallergens and allergic symptoms in an urban population of central Italy: a longitudinal study[J]. Clin Exp Allergy, 2007, 37(2):188-196.
[32] Mbatchou Ngahane B H, Noah D, Nganda Motto M, et al. Sensitization to common aeroallergens in a population of young adults in a sub-Saharan Africa setting: a cross-sectional study[J]. Allergy Asthma Clin Immunol, 2016, 12(1):1.
[33] Yong-Rodríguez A, Macías-Weinmann A, Palma-Gómez S, et al. Profile of sensitization to allergens in children with atopic dermatitis assisting to Allergology Service of University Hospital, Nuevo Leon, Mexico[J]. Rev Alerg Mex, 2015, 62(2):98-106.
[34] Pefura-Yone E W, Mbele-Onana C L, Balkissou A D, et al. for Groupe Enquête en Santé Respiratoire au Cameroun(GESRC). Perennial aeroallergens sensitisation and risk of asthma in African children and adolescents: a case-control study[J]. Asthma, 2015, 52(6):57.
[35] Patelis A, Dosanjh A, Gunnbjörnsdottir M, et al. New data analysis in a population study raises the hypothesis that particle size contributes to the pro-asthmatic potential of small pet animal allergens[J]. Ups J Med Sci, 2015 Nov 26:1-8.
[36] 程雷, 毛晓全, 徐其昌. 变应性鼻炎发病与空气污染饮食和感染的关系[J]. 中华耳鼻咽喉头颈外科杂志, 2003, 38(1):71-73.
[37] Julia V, Macia L, Dombrowicz D. The impact of diet on asthma and allergic diseases[J]. Nat Rev Immunol, 2015, 15(5):308-322.
[38] 顾之燕. 饮食中缺乏抗氧化剂是呼吸道变应性疾病流行的危险因素之一[J]. 中华耳鼻咽喉头颈外科杂志, 2008, 43(1):5-6.
[39] Tamay Z, Akcay A, Ergin A, et al. Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents[J]. Int J Pediatr Otorhinolaryngol, 2013, 77(9):1416-1423.
[40] Tamay Z, Akcay A, Ergin A, et al. Dietary habits and prevalence of allergic rhinitis in 6 to 7-year-old schoolchildren in Turkey[J]. Allergol Int, 2014, 63(4):553-562.
[41] Hao N, Whitelaw M L. The emerging roles of AhR in physiology and immunity[J]. Biochem Pharmacol, 2013, 86(5):561-570.
[42] Nguyen N T, Hanieh H, Nakahama T, et al. The roles of aryl hydrocarbon receptor in immune responses[J]. Int Immunol, 2013, 25(6):335-343.
[43] Hao N, Whitelaw M L. The emerging roles of AhR in physiology and immunity[J]. Biochem Pharmacol, 2013, 86(5):561-570.
[44] Zhou Y, Mirza S, Xu T, et al. Aryl hydrocarbon receptor(AhR)modulates cockroach allergen-induced immune responses through active TGFβ1 release[J]. Mediators Inflamm, 2014, 591479. doi: 10.1155/2014/591479. Epub 2014 Mar 26.
[45] Wei P, Hu G H, Kang H Y, et al. Increased aryl hydrocarbon receptor expression in patients with allergic rhinitis[J]. QJM, 2014, 107(2):107-113.
[46] Veldhoen M, Hirota K, Westendorf A M, et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins[J]. Nature, 2008, 453(7191):106-109.
[47] Quintana F J, Basso A S, Iglesias A H, et al. Control of T(reg)and T(H)17 cell differentiation by the aryl hydrocarbon receptor[J]. Nature, 2008, 453(7191):65-71.
[48] Sim C S, Lee J H, Kim S H, et al. Oxidative stress in schoolchildren with allergic rhinitis: propensity score matching case-control study[J]. Ann Allergy Asthma Immunol, 2015, 115(5):391-395.
[49] Ling Y, Yin-Shi G, Hong-Wei S, et al. Oxidative stress status in umbilical cord blood from neonates born to mothers with atopic asthma[J]. Matern Fetal Neonatal Med, 2014, 27(2):192-196.
[50] Jiang L, Diaz P T, Best T M, et al. Molecular characterization of redox mechanisms in allergic asthma[J]. Ann Allergy Asthma Immunol, 2014, 113(2):137-142.
[51] Comhair S A, Erzurum S C. Redox control of asthma: molecular mechanisms and therapeutic opportunities[J]. Antioxid Redox Signal, 2010, 12(1):93-124.
[52] Rahman I, Adcock I M. Oxidative stress and redox regulation of lung inflammation in COPD[J]. Eur Respir J, 2006, 28(1):219-242.
[53] Carvalho H, Evelson P, Sigaud S, et al. Mitogen-activated protein kinases modulate H(2)O(2)-induced apoptosis in primary rat alveolar epithelial cells[J]. Cell Biochem, 2004, 92(3):502-513.
[54] Kohli A, Garcia M A, Miller R L, et al. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children[J]. Clin Epigenetics, 2012, 4(1):17.
[55] Adenuga D, Yao H, March T H, et al. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke[J]. Am J Respir Cell Mol Biol, 2009, 40(4):464-473.
[56] Liu J, Ballaney M, Al-alem U, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo[J]. Toxicol Sci, 2008, 102:76-81.
[57] Sofer T, Baccarelli A, Cantone L, et al. Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway[J]. Epigenomics, 2013, 5(2):147-154.
[58] Yang I V, Pedersen B S, Liu A, et al. DNA methylation and childhood asthma in the inner city[J]. Allergy Clin Immunol, 2015, 136(1):69-80.
[59] Feng Y, Kong Y, Barnes P F, et al. Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis[J]. Infect Immun, 2011, 79(1):229-237. doi: 10.1128/IAI.00709-10.
[60] Suen J L, Hsu S H, Hung C H, et al. A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma[J]. Allergy, 2013, 68(6):780-787.
[61] Lee J Y, Kang S K, Heo Y J, et al. Influence of flaxseed oil on fecal microbiota, egg quality and fatty acid composition of egg yolks in laying hens[J]. Curr Microbiol, 2016, 72(3):259-66. doi: 10.1007/s00284-015-0946-z.
[62] Lyte M, Chapel A, Lyte J M, et al. Resistant Starch Alters the Microbiota-Gut Brain Axis: Implications for Dietary Modulation of Behavior[J]. PLoS One, 2016, 11(1):e0146406.
[63] Williams B A, Zhang D, Lisle A T, et al. Soluble arabinoxylan enhances large intestinal microbial health biomarkers in pigs fed a red meat-containing diet[J]. Nutrition, 2016, 32(4):491-497. doi: 10.1016/j.nut.2015.10.008.
[64] Shandilya U K, Sharma A, Kapila R, et al. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulatesimmunoglobulin levels and cytokines expression in whey proteins sensitized mice[J]. J Sci Food Agric, 2015 Oct 13. doi: 10.1002/jsfa.7497.[Epub ahead of print]
[65] 张清照,嶋田貴志,程雷. 肠球菌属益生菌提取物LFK对变应性鼻炎小鼠血清IL-12的影响[J]. 山东大学耳鼻喉眼学报, 2014, 28(3):7-9. ZHANG Qingzhao, SHIMADA Takashi, CHENG Lei. Effect of lysed Enterococcus faecalis FK-23(LFK)on serum IL-12 in allergic rhinitis mice[J]. J Otolaryngol Ophthalmol Shandong Univ, 2014, 28(3):7-9.
[66] 朱鲁平, 张清照, 嶋田貴志, 等. 肠球菌属益生菌对实验性变应性鼻炎的抗变态反应作用研究[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(7):555-562. ZHU Luping, ZHANG Qingzhao, SHIMADA Takashi, et al. Anti-allergic effects of the probiotic preparations of Enterococcus on experimental allergic rhinitis in mice[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2013, 48(7):555-562.
[67] Takeda K, Suzuki T, Shimada S I, et al. Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota[J]. Clin Exp Immunol, 2006, 146(1):109-115.
[68] Kwon H K, Lee C G, So J S, et al. Generation of regulatory dendritic cells and CD4+ Foxp3+ T cells by probiotics administration suppresses immune disorders[J]. Proc Natl Acad Sci USA, 2010, 107(5):2159-2164.

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