CO2激光切除累及前联合的早期声门癌26例

doi:10.6040/j.issn.1673-3770.0.2016.019

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (5): 101-105.doi: 10.6040/j.issn.1673-3770.0.2016.019

CO₂激光切除累及前联合的早期声门癌26例

包伟晶¹,宁佳羽²,朱忠寿¹,魏日富¹,林昶³

1.宁德市医院耳鼻咽喉头颈外科, 福建宁德 352100;
2.宁德市医院病理科, 福建宁德 352100;
3.福建医科大学附属第一医院耳鼻喉科, 福建福州 350004

收稿日期:2016-01-18 出版日期:2016-10-20 发布日期:2016-10-20
通讯作者: 林昶. E-mail:linc301@yahoo.com E-mail:baobaoyatou2006@163.co
作者简介:包伟晶. E-mail:baobaoyatou2006@163.co
基金资助:
福建宁德市科技局科研立项指导项目(宁科20140120)

A clinical analysis of CO₂ laser microsurgery for early glottic laryngeal carcinoma with anterior commissure involvement.

BAO Weijing¹, NING Jiayu², ZHU Zhongshou¹, WEI Rifu¹, LIN Chang

1. Department of Otolaryngology &Head and Neck Surgery, Ningde Municipal Hospital, Ningde 352100, Fujian, China;2. Department of Pathology, Ningde Municipal Hospital, Ningde 352100, Fujian, China;3. Department of Otorhinolaryngology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, Fujian, China

Received:2016-01-18 Online:2016-10-20 Published:2016-10-20

摘要/Abstract

摘要： 目的探讨CO₂激光切除侵犯前联合的早期声门癌的临床安全性及疗效。方法回顾性分析26例行CO₂激光治疗的侵犯前联合的早期声门型喉癌患者临床资料,肿瘤标本术中冰冻、术后HE染色行镜下切缘观察,术后严格随访观察局部复发情况。结果切缘阴性20例,阳性6例,随访3年中局部复发7例,复发率为26.9%(7/26),其中切缘阳性复发率为83.3%(5/6),切缘阴性复发率为10%(2/20),组间差异有统计学意义(P=0.002)。结论 CO₂激光治疗累及前联合的早期声门型喉癌喉功能保全良好,疗效可靠,但需严格把握手术适应证以确保切缘安全,降低局部复发率。

关键词: 声门型喉癌, 复发率, 安全切缘, 累及前联合, 激光手术

Abstract: Objective To explore the clinical safety and curative effect of CO₂ laser microsurgery in the treatment of early glottis carcinoma with anterior commissure involvement. Methods Clinical data of 26 cases of early glottic laryngeal carcinoma with anterior commissure involvement treated with CO₂ laser microsurgery were retrospectively analyzed. Surgical specimens were conventionally embedded with paraffin and serially sectioned, and then stained using hematoxylin-eosin for pathologic examination. All patients were closely followed up to observe the local recurrence rate. Results Of all 26 surgical margins, 20 were negative and 6 were positive. Relapse was detected in 7 cases, the recurrence rate being 26.9%(7/26). The recurrence rate of positive and negative surgical margins was 83.3%(5/6)and 10%(2/20), respectively, with statistical differences(P=0.002). Conclusion CO₂ laser microsurgery can safely and effectively preserve the vocal function of early stage glottis carcinoma with anterior commissure involvement. However, the operation indications should be strictly followed in order to guarantee safe surgical excision and reduce local recurrent rate.

Key words: Laser surgery, Anterior commissure involvement, Recurrence rate, Safe surgical margin, Glottis carcinoma

中图分类号:

R739.6

包伟晶,宁佳羽,朱忠寿,魏日富,林昶. CO₂激光切除累及前联合的早期声门癌26例[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 101-105.

BAO Weijing, NING Jiayu, ZHU Zhongshou, WEI Rifu, LIN Chang. A clinical analysis of CO₂ laser microsurgery for early glottic laryngeal carcinoma with anterior commissure involvement.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 101-105.

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CO₂激光切除累及前联合的早期声门癌26例

A clinical analysis of CO₂ laser microsurgery for early glottic laryngeal carcinoma with anterior commissure involvement.

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