声带白斑与癌前病变关系探讨及其研究进展

doi:10.6040/j.issn.1673-3770.0.2016.061

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (6): 90-93.doi: 10.6040/j.issn.1673-3770.0.2016.061

声带白斑与癌前病变关系探讨及其研究进展

王亚琳¹综述,陈剑秋²审校

1.山东中医药大学第二临床学院, 山东济南 250001;
2.济南军区总医院耳鼻咽喉头颈外科, 山东济南 250031

收稿日期:2016-02-20 出版日期:2016-12-16 发布日期:2016-12-16
通讯作者: 陈剑秋. E-mail:jianqiuc2008@aliyun.com E-mail:936398923@qq.co
作者简介:王亚琳. E-mail:936398923@qq.co

Discussion on the relationship between vocal cord leukoplakia and premalignant lesions and research progress of vocal cord leukoplakia.

WANG Yalin¹, CHEN Jianqiu²

1. Second Clinical College of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, General Hospital of Jinan Military Region, Jinan 250031, Shandong, China

Received:2016-02-20 Online:2016-12-16 Published:2016-12-16

摘要/Abstract

摘要： 声带白斑是由刺激因素长期作用于声带黏膜,导致声带黏膜上皮生长异常或成熟异常及过度角化而引起的一种白色斑块样疾病。“白斑”一词,仅为一临床描述性名词,用于描述黏膜上不易擦去的、非特殊病变(例如念珠菌感染)引起的白色病灶。声带白斑多伴有不同程度的不典型增生,有一定的癌变率,但既往将其完全等同于癌前病变有失偏颇,目前已达成共识,认为声带白斑只作为一个临床诊断,本身并无组织病理学暗示。对声带白斑与癌前病变的关系以及声带白斑的形成机制、组织病理学分类、临床诊断及治疗方面进行综述。

关键词: 声带白斑, 癌前病变

Abstract: Vocal cord leukoplakia is a white-plaque disease due to long-term stimulation on vocal cords, which includes abnormal epithelial hypertrophy and dysplasia of the vocal cord. The term “white plaque” is clinically describing any white lesion on a mucous membrane that cannot be wiped off or ascribed to any specific condition(eg, Candidal infection). There is a consensus that vocal cord leukoplakia has no histologic implications and synonymous with cancer or malignancy, only as a clinical descriptive diagnosis. In this paper, we reviewed the relationship between vocal cord leukoplakia and premalignant lesions and the formation mechanism, histopathologic classification, clinical diagnosis and treatment of vocal cord leukoplakia.

Key words: Vocal cord leukoplakia, Premalignant lesions

中图分类号:

R762

王亚琳综述,陈剑秋审校. 声带白斑与癌前病变关系探讨及其研究进展[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 90-93.

WANG Yalin, CHEN Jianqiu. Discussion on the relationship between vocal cord leukoplakia and premalignant lesions and research progress of vocal cord leukoplakia.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 90-93.

参考文献

[1] Pelucchi C, Gallus S, Garavello W, et al. Alcohol and tobacco use, and cancer risk for upper aero digestive tract and liver[J]. Eur J Cancer Prev, 2008, 17(4):340-344.
[2] Weller M D, Nankivell P C, Mcconkey C, et al. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis[J]. Clin Otolaryngol, 2010, 35(5):364-372.
[3] van Hulst A M, Kroon W, van der Linden E S, et al. Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions[J]. Head Neck, 2016, 38(1):2284-2290.
[4] Jackson C. Cancer of the larynx: is it preceded by a recognizable precancerous condition?[J]. Ann Surg, 1923, 77(1):1-14.
[5] Mehanna H, Paleri V, Robson A, et al. Consensus statement by otorhinolaryngologists and pathologists on the diagnosis and management of laryngeal dysplasia[J]. Clin Otolaryngol, 2010, 35(3):170-176.
[6] 杨庆文, 徐文, 叶京英, 等. 声带白斑124例临床及病理分析[J]. 听力学及言语疾病杂志, 2011, 19(5):425-427. YANG Qingwen, XU Wen, YE Jingying, et al. Clinical and pathological analysis for 124 cases of vocal cord leukoplakia[J]. J Audiol Speech Pathol, 2011, 19(5):425-427.
[7] Ma L J, Wang J, Xiao Y, et al. Clinical classification and treatment of leukokeratosis of the vocal cords[J]. Chin Med J(Engl), 2013, 126(18):3523-3527.
[8] Lee D H, Yoon T M, Lee J K, et al. Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia[J]. Eur Arch Otorhinolaryngol, 2015, 272(7):1719-1724.
[9] Pantel M, Guntinas-Lichius O. Laryngeal carcinoma: epidemiology, risk factors and survival[J]. HNO, 2012, 60(1):32-40.
[10] 朱虹, 徐文, 李赟, 等. 声带白斑临床病理特征与咽喉反流的初步观察[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(5):368-373. ZHU Hong, XU Wen, LI Yun, et al. Observation of clinicopathological characteristics of vocal fold leukoplakia and laryngopharyngeal reflux[J]. Chin J Otorhinolarynol Head Neck Surg, 2014, 49(5):368-373.
[11] Isenberg J S, Crozier D L, Dailey S H. Institutional and comprehensive review of laryngeal leukoplakia[J]. Ann Otol Rhinol Laryngol, 2008, 117(1):74-79.
[12] Nina G, Leslie M, Bostjan L, et al. Current review on squamous intraepithelial lesions of the larynx[J]. Histopathology, 2009, 54(6):639-656.
[13] Djukic V, Milovanovic J, Jotic A D, et al. Stroboscopy in detection of laryngeal dysplasia effectiveness and limitations[J]. J Voice, 2014, 28(2):262.e13-262.e21.
[14] 张革化, 黎景佳. 自身荧光内镜在喉癌早期诊断中的应用[J]. 中国医学文摘(耳鼻咽喉科学), 2011, 26(4):205-206. ZHANG Gehua, LI Jingjia. Application of autofluorescence endoscopy in the early diagnosis of laryngeal carcinoma[J]. Chin ENT News Rev, 2011, 26(4):205-206.
[15] 于红, 高圣锐, 孙志, 等. 内镜窄带成像技术在诊断早期喉癌及其癌前病变中的作用研究[J]. 中国实验诊断学, 2015(9):1487-1490. YU Hong, GAO Shengrui, SUN Zhi, et al.The value of narrow band imaging in the diagnosis of early laryngeal cancer and the precancerous lesion[J]. Chin J Lab Diag, 2015(9):1487-1490.
[16] 朱海, 张展. 光学相干断层扫描技术在肿瘤应用的新进展[J]. 世界最新医学信息文摘(连续型电子期刊), 2015, 36:20-21. ZHU Hai, ZHANG Zhan. New advances in the application of optical coherence tomography in tumor[J]. World Latest Med Infor(Continuous Electr J), 2015, 36:20-21.
[17] FerlitoA, Devaney K O, Woolgar J A, et al. Squamous epithelial changes of the larynx: diagnosis and therapy[J]. Head Neck, 2012, 34(12):1810-1816.
[18] 徐文. 声带白斑的诊断与治疗[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(12):1049-1052. XU Wen. The diagnosis and treatment of vocal cord leukoplakia[J]. Chin J Otorhinolarynol Head Neck Surg, 2015, 50(12):1049-1052.
[19] Zhang Y, Liang G, Sun N, et al. Comparison of CO₂ laser and conventional laryngomicrosurgery treatments of polyp and leukoplakia of the vocal fold[J]. Int J Clin Exp Med, 2015, 8(10):18265-18274.
[20] 古庆家, 李静娴, 冯勇, 等. CO₂激光喉显微手术治疗声带白斑疗效观察[J]. 实用医院临床杂志, 2013, 10(4):144-146. GU Qingjia, LI Jingxian, FENG Yong, et al. Efficacy of CO₂ laser treatment of vocal cord leukoplakia under phonomicrosurgery[J]. Prac J Clin Med, 2013, 10(4):144-146.

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声带白斑与癌前病变关系探讨及其研究进展

Discussion on the relationship between vocal cord leukoplakia and premalignant lesions and research progress of vocal cord leukoplakia.

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