山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (1): 103-106.doi: 10.6040/j.issn.1673-3770.0.2016.201

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各型青光眼患者眼内TNF-α及IP-10水平及其相关性分析

童尧1,郑岩1,2,周雅丽1,王艺晓1,赵培泉1,汪朝阳1   

  1. 1.上海交通大学医学院附属新华医院眼科, 上海 200092;
    2.上海交通大学医学院附属新华医院崇明分院眼科, 上海 202150
  • 收稿日期:2016-05-06 出版日期:2017-02-16 发布日期:2017-02-16
  • 通讯作者: 汪朝阳. E-mail:zhaokekewzy@hotmail.com
  • 基金资助:
    国家自然科学基金面上项目(81371040);上海市浦江人才计划(15PJD028)

The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation.

  1. Department of Ophthalmology, 1. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 202150, China
  • Received:2016-05-06 Online:2017-02-16 Published:2017-02-16

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摘要： 目的 探讨各型青光眼患者房水中肿瘤坏死因子-α( TNF-α)和趋化因子-10(IP-10)水平及两种因子之间的相关性。 方法 选取青光眼患者27例为青光眼组,另选取眼压正常的白内障患者28例为对照组,采集房水,用流式微球芯片分析技术进行检测,并对数据进行统计分析。 结果 青光眼患者眼内TNF-α(2.57±0.82)pg/mL及IP-10(990.15±766.84)pg/mL的水平显著高于对照组(P=0.003)。其中,原发性急性闭角型青光眼(AACG)组眼内TNF-α水平显著高于慢性闭角型青光眼(CACG)组;AACG组患者眼内IP-10水平高于CACG组与对照组。此外,青光眼患者眼内IP-10的水平与TNF-α的水平呈正相关(r=0.841, P<0.001)。 结论 TNF-α及IP-10可能参与青光眼的发生与发展,不同发病机制可能导致不同的炎症反应水平,此外,IP-10的水平与TNF-α的水平呈正相关。

关键词: 细胞因子, 肿瘤坏死因子-α, 青光眼, 趋化因子-10

Abstract: Objective To investigate the aqueous levels of tumor necrosis factor-α( TNF-α)and interferon-inducible protein-10( IP-10)in glaucoma and the correlation of them. Methods A total of 27 glaucoma patients were recruited and set as the glaucoma group, and another 28 cataract patients with normal intraocular pressure were also selected as the control group. Aqueous fluid of those patients were collected, and the detection of the concentrations of TNF-αand IP-10 was carried out using the cytometric bead array. The outcomes were further analyzed by SPSS 13.0. Results The mean concentrations of TNF-α and IP-10 in eyes with glaucoma were 2.57±0.82 pg/mL and 990.15±766.84 pg/mL respectively, significantly higher than those of eyes with cataract(P=0.003). In subgroup analysis, the concentration of TNF-α in eyes with acute angle closure glaucoma(AACG)was higher than eyes with chronic angle closure glaucoma(CACG); The concentration of IP-10 in the AACG group was higher than that in the CACG and the control group. Besides, the level of IP-10 was positively correlated with the level of TNF-α(r=0.841, P<0.001). Conclusion TNF-α and IP-10 may play important role in the pathogenesis of glaucoma, and different pathogenesis may lead to different level of inflammatory response. The level of IP-10 was positively correlated with TNF-α.

Key words: Glaucoma, Cytokines, Tumor necrosis factor-α, Interferon-inducible protein-10

中图分类号: 

  • R775.3
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