山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (5): 101-103.doi: 10.6040/j.issn.1673-3770.0.2017.185

• 综述 • 上一篇    下一篇

氧化应激与噪音性聋发病机制及治疗进展

张转,刘涛,白治丽,周长明   

  1. 延安大学附属医院耳鼻喉科, 陕西 延安 716000
  • 收稿日期:2017-04-26 出版日期:2017-10-16 发布日期:2017-10-16
  • 通讯作者: 刘涛. E-mail:hxlt002@163.com
  • 基金资助:
    陕西省科技技术研究发展项目(2013k14-02-27);延安市耳鼻咽喉头颈临床研究科技创新团队(2015CXTD-10);陕西省教育厅科学技术项目资助(2013JK0783)

Evolution of oxidative stress in the pathogenesis and treatment of noise-induced hearing loss.

ZHANG Zhuan, LIU Tao, BAI Zhili, ZHOU Changming   

  1. Department of Otorhinolaryngology, Affiliated Hospital of Yanan University, Yanan 716000, Shaanxi, China
  • Received:2017-04-26 Online:2017-10-16 Published:2017-10-16

摘要: 噪音性聋属常见职业病,其致病机制的研究涉及组织、分子及基因等方面,衍生出机械学说、代谢学说、血管学说、钙离子平衡失调、神经因子缺乏及钾离子循环途径等学说。就氧化应激机制在噪音性聋发病中的作用及治疗进行综述。

关键词: 噪音性聋, 氧化应激, 活性氧

Abstract: Noise-induced hearing loss(NIHL)is a common professional disease. With the improvement in-depth study of recent advances in medicine. The pathogenesis of the disease has been studied from various aspects including the level of molecular and genetic organization, theory of machinery, metabolic theory, theory of blood vessels, imbalance of calcium ions, lack of nerve factors, potassium ion cycle, etc. This paper reviews the role of oxidative stress in the pathogenesis and treatment of NIHL.

Key words: Noise-induced hearing loss, Reactive oxygen species, Oxidative Stress

中图分类号: 

  • R764.43
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