山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (6): 46-48.doi: 10.6040/j.issn.1673-3770.0.2017.290

• 论著 • 上一篇    下一篇

继发性胆脂瘤中CCL27的定位及检测

张孟璐,李永团   

  1. 青岛大学附属青岛市立医院耳鼻咽喉头颈外科, 山东 青岛 266000
  • 收稿日期:2017-07-03 出版日期:2017-12-16 发布日期:2017-12-16
  • 通讯作者: 李永团. E-mail: lytent@126.com

Expression of chemokine ligand 27 in secondary middle ear cholesteatoma.

ZHANG Menglu, LI Yongtuan.   

  1. Department of Otolaryngology &Head and Neck Surgery, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266000, Shandong, China
  • Received:2017-07-03 Online:2017-12-16 Published:2017-12-16

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摘要： 目的 明确趋化因子CCL27在继发性中耳胆脂瘤中的病理学表达,探讨可能的临床意义。 方法 应用免疫组织化学SP法检测CCL27在继发性中耳胆脂瘤(n=30)及正常耳后皮肤组织(n=30)的表达情况,并分析该趋化因子与胆脂瘤病理学之间的联系。 结果 继发性胆脂瘤、耳后皮肤组织中CCL27的阳性率分别为6.7%和33.3%,差异有统计学意义(P=0.021)。 结论 继发性胆脂瘤组织中CCL27的低表达可能与胆脂瘤的增殖过于活跃有关,CCL27可能在继发性中耳胆脂瘤发病过程中扮演重要角色。

关键词: 继发性中耳胆脂瘤, 免疫组化, CCL27

Abstract: Objective To explore the pathological expression of chemokine ligand 27(CCL27)and discuss its possible clinical significance in secondary middle ear cholesteatoma. Methods The SP immunohistochemical staining technique was applied to detect the expression of CCL27 in 30 samples of secondary middle ear cholesteatoma tissue and 30 samples of normal auricle skin. Results Of the secondary middle ear cholesteatoma tissue samples, 6.7% were positive for CCL27 expression, whereas 33.3% of the normal auricle skin samples were positive for CCL27 expression. CCL27 was expressed less commonly in the former, and there was a significant difference in the rate of expression between the two groups(P=0.021). Conclusion The lower expression of CCL27 may be correlated with the hyperproliferative nature of the secondary middle ear cholesteatoma epithelium. CCL27 may play a significant role in the development of secondary middle ear cholesteatoma.

Key words: Immunohistochemistry, CCL27, Secondary middle ear cholesteatoma

中图分类号: 

  • R764.21
[1] Habesoglu TE, Balak N, Habesoglu M, et al. Intracranial cholesteatoma: a case report and review[J]. J Emerg Med, 2007, 32(4): 375-379.
[2] Olszewska E, Wagner M, Bernal-Sprekelsen M, et al. Etiopathogenesis of cholesteatoma[J]. Eur Arch Otorhinolaryngol, 2004, 261(1): 6-24.
[3] Quaranta N, Cassano M, Quaranta A. Facial paralysis associated with cholesteatoma: a review of 13 cases[J]. Otol Neurotol, 2007, 28(3): 405-407.
[4] Migirov L, Bendet E, Kronenberg J. Cholesteatoma invasion into the internal auditory canal[J]. Eur Arch Otorhinolaryngol, 2009, 266(5): 657-662.
[5] Morales J, Homey B, Vicari AP, et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells[J]. Proc Natl Acad Sci U S A, 1999, 96(25): 14470-14475.
[6] Riis JL, Johansen C, Vestergaard C, et al. CCL27 expression is regulated by both p38 MAPK and IKKbeta signalling pathways[J]. Cytokine, 2011, 56(3): 699-707.
[7] Homey B, Alenius H, Muller A, et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation[J]. Nat Med, 2002, 8(2): 157-165.
[8] Inokuma D, Abe R, Fujita Y, et al. CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytes[J]. Stem Cells, 2006, 24(12): 2810-2816.
[9] Pivarcsi A, Muller A, Hippe A, et al. Tumor immune escape by the loss of homeostatic chemokine expression[J]. Proc Natl Acad Sci U S A, 2007, 104(48): 19055-19060.
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